UniProt ID: Q800V0 |
FUNCTION: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. {ECO:0000256|PIRNR:PIRNR000333}. CATALYTIC ACTIVITY: Reaction=H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide; Xref=Rhea:RHEA:19897, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16480, ChEBI:CHEBI:32682, ChEBI:CHEBI:57743, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.14.13.39; Evidence={ECO:0000256|ARBA:ARBA00001639, ECO:0000256|PIRNR:PIRNR000333}; COFACTOR: Name=(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin; Xref=ChEBI:CHEBI:59560; Evidence={ECO:0000256|ARBA:ARBA00001950}; COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000256|PIRNR:PIRNR000333}; Note=Binds 1 FAD. {ECO:0000256|PIRNR:PIRNR000333}; COFACTOR: Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence={ECO:0000256|PIRNR:PIRNR000333}; Note=Binds 1 FMN. {ECO:0000256|PIRNR:PIRNR000333}; COFACTOR: Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence={ECO:0000256|ARBA:ARBA00001970, ECO:0000256|PIRNR:PIRNR000333}; SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000256|ARBA:ARBA00004468}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004468}. Cell projection, dendritic spine {ECO:0000256|ARBA:ARBA00004552}. SIMILARITY: Belongs to the NOS family. {ECO:0000256|ARBA:ARBA00006267, ECO:0000256|PIRNR:PIRNR000333}. |
UniProt ID: A0A0R4IQG7 |
FUNCTION: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. {ECO:0000256|PIRNR:PIRNR000333}. CATALYTIC ACTIVITY: Reaction=H(+) + 2 L-arginine + 3 NADPH + 4 O2 = 4 H2O + 2 L-citrulline + 3 NADP(+) + 2 nitric oxide; Xref=Rhea:RHEA:19897, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:16480, ChEBI:CHEBI:32682, ChEBI:CHEBI:57743, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.14.13.39; Evidence={ECO:0000256|ARBA:ARBA00001639, ECO:0000256|PIRNR:PIRNR000333}; COFACTOR: Name=(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin; Xref=ChEBI:CHEBI:59560; Evidence={ECO:0000256|ARBA:ARBA00001950}; COFACTOR: Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000256|PIRNR:PIRNR000333}; Note=Binds 1 FAD. {ECO:0000256|PIRNR:PIRNR000333}; COFACTOR: Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence={ECO:0000256|PIRNR:PIRNR000333}; Note=Binds 1 FMN. {ECO:0000256|PIRNR:PIRNR000333}; COFACTOR: Name=heme b; Xref=ChEBI:CHEBI:60344; Evidence={ECO:0000256|ARBA:ARBA00001970, ECO:0000256|PIRNR:PIRNR000333}; SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000256|ARBA:ARBA00004468}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004468}. Cell projection, dendritic spine {ECO:0000256|ARBA:ARBA00004552}. SIMILARITY: Belongs to the NOS family. {ECO:0000256|ARBA:ARBA00006267, ECO:0000256|PIRNR:PIRNR000333}. |
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