UniProt ID: Q9I9H8 |
FUNCTION: Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP (By similarity). {ECO:0000250}. SUBUNIT: Monomer. Oligomerizes upon binding of cytochrome c and dATP (By similarity). {ECO:0000250}. SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. |
UniProt ID: A0A8M2BC28 |
FUNCTION: Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. {ECO:0000256|PIRNR:PIRNR037646}. SUBUNIT: Monomer. Oligomerizes upon binding of cytochrome c and dATP. {ECO:0000256|PIRNR:PIRNR037646}. SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR037646}. |
This information was provided by UniProt through a collaboration with ZFIN. (1) |