UniProt ID: B2GS08
SIMILARITY: Belongs to the actin family. {ECO:0000256|RuleBase:RU000487}.
UniProt ID: A0A2R8QB43
SIMILARITY: Belongs to the actin family. {ECO:0000256|RuleBase:RU000487}.
UniProt ID: Q7ZVI7
FUNCTION: Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. {ECO:0000250|UniProtKB:P60709}.
SUBUNIT: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix (By similarity). Each actin can bind to 4 others (By similarity). {ECO:0000250|UniProtKB:P60709, ECO:0000250|UniProtKB:P60710}.
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P60710}. Nucleus {ECO:0000250|UniProtKB:O93400}.
TISSUE SPECIFICITY: Skeletal muscle, heart, gill, digestive tissue and brain (PubMed:9987040). Widespread expression throughout the brain, with highest levels in regions where neuronal proliferation is greatest (PubMed:9987040). {ECO:0000269|PubMed:9987040}.
PTM: Oxidation of Met-44 and Met-47 by MICALs (mical1, mical2 or mical3) to form methionine sulfoxide promotes actin filament depolymerization. Mical1 and mical2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by msrb1 and msrb2, which promote actin repolymerization (By similarity). {ECO:0000250|UniProtKB:P60710}.
PTM: Methylation at His-73 by SETD3. Methylation stabilizes actin filaments. {ECO:0000250|UniProtKB:P60706}.
MISCELLANEOUS: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. {ECO:0000250|UniProtKB:O93400}.
SIMILARITY: Belongs to the actin family. {ECO:0000305}.
UniProt ID: E9QD59
SIMILARITY: Belongs to the actin family. {ECO:0000256|RuleBase:RU000487}.
UniProt ID: E9QBP3
SIMILARITY: Belongs to the actin family. {ECO:0000256|RuleBase:RU000487}.
UniProt ID: C5IG37
SIMILARITY: Belongs to the actin family. {ECO:0000256|RuleBase:RU000487}.
UniProt ID: E9QH14
SIMILARITY: Belongs to the actin family. {ECO:0000256|RuleBase:RU000487}.
This information was provided by UniProt through a collaboration with ZFIN. (1)