UniProt ID: Q9PTS2 |
FUNCTION: Catalyzes the sequential decarboxylation of the four acetate side chains of uroporphyrinogen to form coproporphyrinogen and participates in the fifth step in the heme biosynthetic pathway. Isomer I or isomer III of uroporphyrinogen may serve as substrate, but only coproporphyrinogen III can ultimately be converted to heme (By similarity). In vitro also decarboxylates pentacarboxylate porphyrinogen I (PubMed:9806541). {ECO:0000250|UniProtKB:P06132, ECO:0000269|PubMed:9806541}. CATALYTIC ACTIVITY: Reaction=4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III; Xref=Rhea:RHEA:19865, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57308, ChEBI:CHEBI:57309; EC=4.1.1.37; Evidence={ECO:0000250|UniProtKB:P06132}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19866; Evidence={ECO:0000250|UniProtKB:P06132}; CATALYTIC ACTIVITY: Reaction=4 H(+) + uroporphyrinogen I = 4 CO2 + coproporphyrinogen I; Xref=Rhea:RHEA:31239, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:62626, ChEBI:CHEBI:62631; Evidence={ECO:0000250|UniProtKB:P06132}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:31240; Evidence={ECO:0000250|UniProtKB:P06132}; PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. {ECO:0000250|UniProtKB:P06132}. SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:P06132}. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the uroporphyrinogen decarboxylase family. {ECO:0000305}. |
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