Ablain, J., Xu, M., Rothschild, H., Jordan, R.C., Mito, J.K., Daniels, B.H., Bell, C.F., Joseph, N.M., Wu, H., Bastian, B.C., Zon, L.I., Yeh, I. (2018) Human tumor genomics and zebrafish modeling identify SPRED1 loss as a driver of mucosal melanoma.. Science (New York, N.Y.). 362(6418):1055-1060

Banjo, T., Grajcarek, J., Yoshino, D., Osada, H., Miyasaka, K.Y., Kida, Y.S., Ueki, Y., Nagayama, K., Kawakami, K., Matsumoto, T., Sato, M., and Ogura, T. (2013) Haemodynamically dependent valvulogenesis of zebrafish heart is mediated by flow-dependent expression of miR-21. Nature communications. 4:1978

Blokzijl-Franke, S., Ponsioen, B., Schulte-Merker, S., Herbomel, P., Kissa, K., Choorapoikayil, S., den Hertog, J. (2021) Phosphatidylinositol-3 kinase signaling controls survival and stemness of hematopoietic stem and progenitor cells. Oncogene. 40(15):2741-2755

Choorapoikayil, S., Kuiper, R.V., de Bruin, A., and den Hertog, J. (2012) Haploinsufficiency of tumor suppressor pten predisposes to hemangiosarcoma in zebrafish. Disease models & mechanisms. 5(2):241-247

Ciarlo, C., Kaufman, C.K., Kinikoglu, B., Michael, J., Yang, S., D Amato, C., Blokzijl-Franke, S., den Hertog, J., Schlaeger, T.M., Zhou, Y., Liao, E., Zon, L.I. (2017) A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development. eLIFE. 6

Costa, M.M., Saraceni, P.R., Forn-Cuní, G., Dios, S., Romero, A., Figueras, A., and Novoa, B. (2013) IL-22 is a key player in the regulation of inflammation in fish and involves innate immune cells and PI3K signaling. Developmental and comparative immunology. 41(4):746-755

Dong, Z.W., Ren, C.G., Xia, Y., Su, D., Du, T.T., Fan, H.B., Yuan, H., Wang, L., Dong, M., Li, W.C., Jin, Y., Chen, Y., Deng, M., Liu, T.X., Gu, A.H., Zhou, Y. (2014) Pten regulates homeostasis and inflammation-induced migration of myelocytes in zebrafish. Journal of Hematology & Oncology. 7:17

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

Feng, N., Bian, Z., Zhang, X., Wang, C., Chen, J. (2018) Rapamycin reduces mortality in acute-stage paraquat-induced toxicity in zebrafish. Singapore medical journal. 60(5):241-246

Fu, C.T., Zhu, K.Y., Mi, J.Q., Liu, Y.F., Murray, S.T., Fu, Y.F., Ren, C.G., Dong, Z.W., Liu, Y.J., Dong, M., Jin, Y., Chen, Y., Deng, M., Zhang, W., Chen, B., Breslin, P., Chen, S.J., Chen, Z., Becker, M.W., Zhu, J., Zhang, J.W., and Liu, T.X. (2010) An evolutionarily conserved PTEN-C/EBP{alpha}-CTNNA1 axis controls myeloid development and transformation. Blood. 115(23):4715-4724

Gutierrez, A., Grebliunaite, R., Feng, H., Kozakewich, E., Zhu, S., Guo, F., Payne, E., Mansour, M., Dahlberg, S.E., Neuberg, D.S., Hertog, J.D., Prochownik, E.V., Testa, J.R., Harris, M., Kanki, J.P., and Look, A.T. (2011) Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia. The Journal of experimental medicine. 208(8):1595-603

He, S., Zimmerman, M.W., Layden, H.M., Berezovskaya, A., Etchin, J., Martel, M.W., Thurston, G., Jing, C.B., van Rooijen, E., Kaufman, C.K., Rodig, S.J., Zon, L.I., Patton, E.E., Mansour, M.R., Look, A.T. (2021) Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss. Oncogene. 40(38):5718-5729

Jagadeeshan, S., Sagayaraj, R.V., Paneerselvan, N., Ghouse, S.S., Malathi, R. (2017) Toxicity and anti-angiogenicity evaluation of Pak1 inhibitor IPA-3 using zebrafish embryo model. Cell biology and toxicology. 33(1):41-56

Kok, F.O., Shin, M., Ni, C., Gupta, A., Grosse, A.S., van Impel, A., Kirchmaier, B.C., Peterson-Maduro, J., Kourkoulis, G., Male, I., DeSantis, D.F., Sheppard-Tindell, S., Ebarasi, L., Betsholtz, C., Schulte-Merker, S., Wolfe, S.A., Lawson, N.D. (2015) Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish. Developmental Cell. 32(1):97-108

Lai, C.Y., Yeh, K.Y., Liu, B.F., Chang, T.M., Chang, C.H., Liao, Y.F., Liu, Y.W., Her, G.M. (2021) MicroRNA-21 Plays Multiple Oncometabolic Roles in Colitis-Associated Carcinoma and Colorectal Cancer via the PI3K/AKT, STAT3, and PDCD4/TNF-α Signaling Pathways in Zebrafish. Cancers. 13(21):

Lin, C., Lin, C.N., Wang, Y.C., Liu, F.Y., Chien, Y.W., Chuang, Y.J., Lan, C.Y., Hsieh, W.P., Chen, B.S. (2014) Robustness analysis on interspecies interaction network for iron and glucose competition between Candida albicans and zebrafish during infection. BMC systems biology. 8 Suppl 5:S6

Liu, D.J., Zhang, F., Chen, Y., Jin, Y., Zhang, Y.L., Chen, S.B., Xie, Y.Y., Huang, Q.H., Zhao, W.L., Wang, L., Xu, P.F., Chen, Z., Chen, S.J., Li, B., Zhang, A., Sun, X.J. (2020) setd2 knockout zebrafish is viable and fertile: differential and developmental stress-related requirements for Setd2 and histone H3K36 trimethylation in different vertebrate animals. Cell discovery. 6:72

McCarthy, N., Wetherill, L., Lovely, C.B., Swartz, M.E., Foroud, T.M., and Eberhart, J.K. (2013) Pdgfra protects against ethanol-induced craniofacial defects in a zebrafish model of FASD. Development (Cambridge, England). 140(15):3254-3265

Overman, J.P., and den Hertog, J. (2014) Zebrafish as a model to study PTPs during development. Methods (San Diego, Calif.). 65(2):247-53

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

Stumpf, M., den Hertog, J. (2016) Differential Requirement for Pten Lipid and Protein Phosphatase Activity during Zebrafish Embryonic Development. PLoS One. 11:e0148508

Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735

Wang, Y., Zhong, H., Wang, C., Gao, D., Zhou, Y., Zuo, Z. (2016) Maternal exposure to the water soluble fraction of crude oil, lead and their mixture induces autism-like behavioral deficits in zebrafish (Danio rerio) larvae. Ecotoxicology and environmental safety. 134P1:23-30

Winata, C.L., Kondrychyn, I., Kumar, V., Srinivasan, K.G., Orlov, Y., Ravishankar, A., Prabhakar, S., Stanton, L.W., Korzh, V., and Mathavan, S. (2013) Genome wide analysis reveals zic3 interaction with distal regulatory elements of stage specific developmental genes in zebrafish. PLoS Genetics. 9(10):e1003852

Zhao, F., Shi, Y., Huang, Y., Zhan, Y., Zhou, L., Li, Y., Wan, Y., Li, H., Huang, H., Ruan, H., Luo, L., Li, L. (2017) Irf8 regulates the progression of myeloproliferative neoplasm (MPN)-like syndrome via Mertk signaling in zebrafish. Leukemia. 32(1):149-158

Geng, Y., Zhang, T., Alonzo, I.G., Godar, S.C., Yates, C., Pluimer, B.R., Harrison, D.L., Nath, A.K., Yeh, J.J., Drummond, I.A., Bortolato, M., Peterson, R.T. (2022) Top2a promotes the development of social behavior via PRC2 and H3K27me3. Science advances. 8:eabm7069eabm7069

Baggiolini, A., Callahan, S.J., Montal, E., Weiss, J.M., Trieu, T., Tagore, M.M., Tischfield, S.E., Walsh, R.M., Suresh, S., Fan, Y., Campbell, N.R., Perlee, S.C., Saurat, N., Hunter, M.V., Simon-Vermot, T., Huang, T.H., Ma, Y., Hollmann, T., Tickoo, S.K., Taylor, B.S., Khurana, E., Koche, R.P., Studer, L., White, R.M. (2021) Developmental chromatin programs determine oncogenic competence in melanoma. Science (New York, N.Y.). 373:eabc1048

He, S., Zimmerman, M.W., Layden, H.M., Berezovskaya, A., Etchin, J., Martel, M.W., Thurston, G., Jing, C.B., van Rooijen, E., Kaufman, C.K., Rodig, S.J., Zon, L.I., Patton, E.E., Mansour, M.R., Look, A.T. (2021) Synergistic melanoma cell death mediated by inhibition of both MCL1 and BCL2 in high-risk tumors driven by NF1/PTEN loss. Oncogene. 40(38):5718-5729

Lai, C.Y., Yeh, K.Y., Liu, B.F., Chang, T.M., Chang, C.H., Liao, Y.F., Liu, Y.W., Her, G.M. (2021) MicroRNA-21 Plays Multiple Oncometabolic Roles in Colitis-Associated Carcinoma and Colorectal Cancer via the PI3K/AKT, STAT3, and PDCD4/TNF-α Signaling Pathways in Zebrafish. Cancers. 13(21):

Jung, K., Kim, M., So, J., Lee, S.H., Ko, S., Shin, D. (2020) Farnesoid X receptor activation impairs liver progenitor cell-mediated liver regeneration via the PTEN-PI3K-AKT-mTOR axis in zebrafish. Hepatology (Baltimore, Md.). 74(1):397-410

Liu, D.J., Zhang, F., Chen, Y., Jin, Y., Zhang, Y.L., Chen, S.B., Xie, Y.Y., Huang, Q.H., Zhao, W.L., Wang, L., Xu, P.F., Chen, Z., Chen, S.J., Li, B., Zhang, A., Sun, X.J. (2020) setd2 knockout zebrafish is viable and fertile: differential and developmental stress-related requirements for Setd2 and histone H3K36 trimethylation in different vertebrate animals. Cell discovery. 6:72

Zhao, W., Cao, L., Ying, H., Zhang, W., Li, D., Zhu, X., Xue, W., Wu, S., Cao, M., Fu, C., Qi, H., Hao, Y., Tang, Y.C., Qin, J., Zhong, T.P., Lin, X., Yu, L., Li, X., Li, L., Wu, D., Pan, W. (2019) Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition. Cell Research. 29(11):895-910

Feng, N., Bian, Z., Zhang, X., Wang, C., Chen, J. (2018) Rapamycin reduces mortality in acute-stage paraquat-induced toxicity in zebrafish. Singapore medical journal. 60(5):241-246

Hale, A.J., Kiai, A., Sikkens, J., den Hertog, J. (2017) Impaired caudal fin-fold regeneration in zebrafish deficient for the tumor suppressor Pten. Regeneration (Oxford, England). 4:217-226

Jagadeeshan, S., Sagayaraj, R.V., Paneerselvan, N., Ghouse, S.S., Malathi, R. (2017) Toxicity and anti-angiogenicity evaluation of Pak1 inhibitor IPA-3 using zebrafish embryo model. Cell biology and toxicology. 33(1):41-56

Zhao, F., Shi, Y., Huang, Y., Zhan, Y., Zhou, L., Li, Y., Wan, Y., Li, H., Huang, H., Ruan, H., Luo, L., Li, L. (2017) Irf8 regulates the progression of myeloproliferative neoplasm (MPN)-like syndrome via Mertk signaling in zebrafish. Leukemia. 32(1):149-158

Stumpf, M., den Hertog, J. (2016) Differential Requirement for Pten Lipid and Protein Phosphatase Activity during Zebrafish Embryonic Development. PLoS One. 11:e0148508

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

Blackburn, J.S., Liu, S., Wilder, J.L., Dobrinski, K.P., Lobbardi, R., Moore, F.E., Martinez, S.A., Chen, E.Y., Lee, C., Langenau, D.M. (2014) Clonal evolution enhances leukemia-propagating cell frequency in T cell acute lymphoblastic leukemia through Akt/mTORC1 pathway activation. Cancer Cell. 25:366-78

Corrales, J., Fang, X., Thornton, C., Mei, W., Barbazuk, W.B., Duke, M., Scheffler, B.E., Willett, K.L. (2014) Effects on specific promoter DNA methylation in zebrafish embryos and larvae following benzo[a]pyrene exposure. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 163:37-46

Lin, C., Lin, C.N., Wang, Y.C., Liu, F.Y., Chien, Y.W., Chuang, Y.J., Lan, C.Y., Hsieh, W.P., Chen, B.S. (2014) Robustness analysis on interspecies interaction network for iron and glucose competition between Candida albicans and zebrafish during infection. BMC systems biology. 8 Suppl 5:S6

Overman, J.P., and den Hertog, J. (2014) Zebrafish as a model to study PTPs during development. Methods (San Diego, Calif.). 65(2):247-53

Choorapoikayil, S., Weijts, B., Kers, R., de Bruin, A., and den Hertog, J. (2013) Loss of Pten promotes angiogenesis and enhanced vegfaa expression in zebrafish. Disease models & mechanisms. 6(5):1159-66

McCarthy, N., Wetherill, L., Lovely, C.B., Swartz, M.E., Foroud, T.M., and Eberhart, J.K. (2013) Pdgfra protects against ethanol-induced craniofacial defects in a zebrafish model of FASD. Development (Cambridge, England). 140(15):3254-3265

Winata, C.L., Kondrychyn, I., Kumar, V., Srinivasan, K.G., Orlov, Y., Ravishankar, A., Prabhakar, S., Stanton, L.W., Korzh, V., and Mathavan, S. (2013) Genome wide analysis reveals zic3 interaction with distal regulatory elements of stage specific developmental genes in zebrafish. PLoS Genetics. 9(10):e1003852

Moore, F.E., Reyon, D., Sander, J.D., Martinez, S.A., Blackburn, J.S., Khayter, C., Ramirez, C.L., Joung, J.K., and Langenau, D.M. (2012) Improved Somatic Mutagenesis in Zebrafish Using Transcription Activator-Like Effector Nucleases (TALENs). PLoS One. 7(5):e37877

Gutierrez, A., Grebliunaite, R., Feng, H., Kozakewich, E., Zhu, S., Guo, F., Payne, E., Mansour, M., Dahlberg, S.E., Neuberg, D.S., Hertog, J.D., Prochownik, E.V., Testa, J.R., Harris, M., Kanki, J.P., and Look, A.T. (2011) Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia. The Journal of experimental medicine. 208(8):1595-603

Fu, C.T., Zhu, K.Y., Mi, J.Q., Liu, Y.F., Murray, S.T., Fu, Y.F., Ren, C.G., Dong, Z.W., Liu, Y.J., Dong, M., Jin, Y., Chen, Y., Deng, M., Zhang, W., Chen, B., Breslin, P., Chen, S.J., Chen, Z., Becker, M.W., Zhu, J., Zhang, J.W., and Liu, T.X. (2010) An evolutionarily conserved PTEN-C/EBP{alpha}-CTNNA1 axis controls myeloid development and transformation. Blood. 115(23):4715-4724

Faucherre, A., Taylor, G.S., Overvoorde, J., Dixon, J.E., and Hertog, J.D. (2008) Zebrafish pten genes have overlapping and non-redundant functions in tumorigenesis and embryonic development. Oncogene. 27(8):1079-1086

Croushore, J.A., Blasiole, B., Riddle, R.C., Thisse, C., Thisse, B., Canfield, V.A., Robertson, G.P., Cheng, K.C., and Levenson, R. (2005) Ptena and ptenb genes play distinct roles in zebrafish embryogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 234(4):911-921