ZFIN

ZFIN ID: ZDB-GENE-000616-4

ZFIN ID: ZDB-GENE-000616-4

CITATIONS (76 total)

Gene Name:	apoptotic peptidase activating factor 1
Gene Symbol:	apaf1

Gao, M., Hu, J., Zhu, Y., Wang, X., Zeng, S., Hong, Y., Zhao, G. (2022) Ferroptosis and Apoptosis Are Involved in the Formation of L-Selenomethionine-Induced Ocular Defects in Zebrafish Embryos. International Journal of Molecular Sciences. 23(9)

Xie, Z., Lu, G., Zhou, R., Ma, Y. (2022) Thiacloprid-induced hepatotoxicity in zebrafish: Activation of the extrinsic and intrinsic apoptosis pathways regulated by p53 signaling pathway. Aquatic toxicology (Amsterdam, Netherlands). 246:106147

Chen, X., Zheng, J., Teng, M., Zhang, J., Qian, L., Duan, M., Zhao, F., Zhao, W., Wang, Z., Wang, C. (2021) Bioaccumulation, Metabolism and the Toxic Effects of Chlorfenapyr in Zebrafish (Danio rerio). Journal of Agricultural and Food Chemistry. 69(29):8110-8119

Godoi, F.G.A., Forner-Piquer, I., Randazzo, B., Habibi, H.R., Lo Nostro, F.L., Moreira, R.G., Carnevali, O. (2021) Effects of Di-Isononyl Phthalate (DiNP) on Follicular Atresia in Zebrafish Ovary. Frontiers in endocrinology. 12:677853

Qiang, L., Cheng, J. (2021) Exposure to polystyrene microplastics impairs gonads of zebrafish (Danio rerio). Chemosphere. 263:128161

Rossmann, M.P., Hoi, K., Chan, V., Abraham, B.J., Yang, S., Mullahoo, J., Papanastasiou, M., Wang, Y., Elia, I., Perlin, J.R., Hagedorn, E.J., Hetzel, S., Weigert, R., Vyas, S., Nag, P.P., Sullivan, L.B., Warren, C.R., Dorjsuren, B., Greig, E.C., Adatto, I., Cowan, C.A., Schreiber, S.L., Young, R.A., Meissner, A., Haigis, M.C., Hekimi, S., Carr, S.A., Zon, L.I. (2021) Cell-specific transcriptional control of mitochondrial metabolism by TIF1γ drives erythropoiesis. Science (New York, N.Y.). 372:716-721

Sun, C.C., Zhou, Z.Q., Chen, Z.L., Zhu, R.K., Yang, D., Peng, X.Y., Zheng, L., Tang, C.F. (2021) Identification of Potentially Related Genes and Mechanisms Involved in Skeletal Muscle Atrophy Induced by Excessive Exercise in Zebrafish. Biology. 10(8):

Yang, G., Wang, Y., Wang, T., Wang, D., Weng, H., Wang, Q., Chen, C. (2021) Variations of enzymatic activity and gene expression in zebrafish (Danio rerio) embryos co-exposed to zearalenone and fumonisin B1. Ecotoxicology and environmental safety. 222:112533

Nguyen, T.H., Nguyen, P.D., Quetin-Leclercq, J., Muller, M., Ly Huong, D.T., Pham, H.T., Kestemont, P. (2020) Developmental toxicity of Clerodendrum cyrtophyllum turcz ethanol extract in zebrafish embryo. Journal of ethnopharmacology. 267:113538

Shang, X., Ji, X., Dang, J., Wang, L., Sun, C., Liu, K., Sik, A., Jin, M. (2020) α-asarone induces cardiac defects and QT prolongation through mitochondrial apoptosis pathway in zebrafish. Toxicology letters. 324:1-11

Zhou, W., Wang, J., Zhang, J., Peng, C., Li, G., Li, D. (2020) Environmentally relevant concentrations of geosmin affect the development, oxidative stress, apoptosis and endocrine disruption of embryo-larval zebrafish. The Science of the total environment. 735:139373

Teng, M., Zhou, Y., Song, M., Dong, K., Chen, X., Wang, C., Bi, S., Zhu, W. (2019) Chronic toxic effects of flutolanil on the liver of zebrafish (Danio rerio). Chemical Research in Toxicology. 32(6):995-1001

Yuan, L., Qian, L., Qian, Y., Liu, J., Yang, K., Huang, Y., Wang, C., Li, Y., Mu, X. (2019) Bisphenol F-induced neurotoxicity towards zebrafish embryos. Environmental science & technology. 53(24):14638-14648

Zhao, F., Li, H., Cao, F., Chen, X., Liang, Y., Qiu, L. (2019) Short-term developmental toxicity and potential mechanisms of the herbicide metamifop to zebrafish (Danio rerio) embryos. Chemosphere. 236:124590

Cao, F., Wu, P., Huang, L., Li, H., Qian, L., Pang, S., Qiu, L. (2018) Short-term developmental effects and potential mechanisms of azoxystrobin in larval and adult zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 198:129-140

Chai, T., Cui, F., Song, Y., Ye, L., Li, T., Qiu, J., Liu, X. (2018) Enantioselective Toxicity in Adult Zebrafish (Danio rerio) Induced by Chiral PCB91 through Multiple Pathways. Environmental science & technology. 52(9):5448-5458

Jiang, J., Lv, L., Wu, S., An, X., Wang, F., Liu, X., Zhao, X. (2018) Developmental toxicity of kresoxim-methyl during zebrafish (Danio rerio) larval development. Chemosphere. 219:517-525

Jiang, J., Shi, Y., Yu, R., Chen, L., Zhao, X. (2018) Biological response of zebrafish after short-term exposure to azoxystrobin. Chemosphere. 202:56-64

Qian, L., Cui, F., Yang, Y., Liu, Y., Qi, S., Wang, C. (2018) Mechanisms of developmental toxicity in zebrafish embryos (Danio rerio) induced by boscalid. The Science of the total environment. 634:478-487

Wu, S., Li, X., Liu, X., Yang, G., An, X., Wang, Q., Wang, Y. (2018) Joint toxic effects of triazophos and imidacloprid on zebrafish (Danio rerio). Environmental pollution (Barking, Essex : 1987). 235:470-481

Xia, Q., Wei, L., Zhang, Y., Kong, H., Shi, Y., Wang, X., Chen, X., Han, L., Liu, K. (2018) Psoralen Induces Developmental Toxicity in Zebrafish Embryos/Larvae Through Oxidative Stress, Apoptosis, and Energy Metabolism Disorder. Frontiers in pharmacology. 9:1457

Shi, G., Xie, Y., Guo, Y., Dai, J. (2017) 6:2 fluorotelomer sulfonamide alkylbetaine (6:2 FTAB), a novel perfluorooctane sulfonate alternative, induced developmental toxicity in zebrafish embryos. Aquatic toxicology (Amsterdam, Netherlands). 195:24-32

Howe, K., Schiffer, P.H., Zielinski, J., Wiehe, T., Laird, G.K., Marioni, J.C., Soylemez, O., Kondrashov, F., Leptin, M. (2016) Structure and evolutionary history of a large family of NLR proteins in the zebrafish. Open Biology. 6(4):160009

Hrubik, J., Glisic, B., Samardzija, D., Stanic, B., Pogrmic-Majkic, K., Fa, S., Andric, N. (2016) Effect of PMA-induced protein kinase C activation on development and apoptosis in early zebrafish embryos. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 190:24-31

Hu, P., Liu, M., Liu, Y., Wang, J., Zhang, D., Niu, H., Jiang, S., Wang, J., Zhang, D., Han, B., Xu, Q., Chen, L. (2016) Transcriptome comparison reveals a genetic network regulating the lower temperature limit in fish. Scientific Reports. 6:28952

Jiang, J., Chen, Y., Yu, R., Zhao, X., Wang, Q., Cai, L. (2016) Pretilachlor has the potential to induce endocrine disruption, oxidative stress, apoptosis and immunotoxicity during zebrafish embryo development. Environmental Toxicology and Pharmacology. 42:125-134

Yang, Y., Liu, W., Mu, X., Qi, S., Fu, B., Wang, C. (2016) Biological response of zebrafish embryos after short-term exposure to thifluzamide. Scientific Reports. 6:38485

Yang, Y., Qi, S., Wang, D., Wang, K., Zhu, L., Chai, T., Wang, C. (2016) Toxic effects of thifluzamide on zebrafish (Danio rerio). Journal of hazardous materials. 307:127-136

Zhao, X., Ren, X., Zhu, R., Luo, Z., Ren, B. (2016) Zinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria-mediated apoptosis in zebrafish embryos. Aquatic toxicology (Amsterdam, Netherlands). 180:56-70

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

Jiang, J., Wu, S., Liu, X., Wang, Y., An, X., Cai, L., Zhao, X. (2015) Effect of acetochlor on transcription of genes associated with oxidative stress, apoptosis, immunotoxicity and endocrine disruption in the early life stage of zebrafish. Environmental Toxicology and Pharmacology. 40:516-523

Jiang, J., Wu, S., Wang, Y., An, X., Cai, L., Zhao, X., Wu, C. (2015) Carbendazim has the potential to induce oxidative stress, apoptosis, immunotoxicity and endocrine disruption during zebrafish larvae development. Toxicology in vitro : an international journal published in association with BIBRA. 29(7):1473-81

Jung, I.H., Choi, J.H., Chung, Y.Y., Lim, G.L., Park, Y.N., Park, S.W. (2015) Predominant Activation of JAK/STAT3 Pathway by Interleukin-6 Is Implicated in Hepatocarcinogenesis. Neoplasia (New York, N.Y.). 17:586-97

Mu, X., Chai, T., Wang, K., Zhang, J., Zhu, L., Li, X., Wang, C. (2015) Occurrence and origin of sensitivity toward difenoconazole in zebrafish (Danio reio) during different life stages. Aquatic toxicology (Amsterdam, Netherlands). 160C:57-68

Wang, Y., Xu, L., Li, D., Teng, M., Zhang, R., Zhou, Z., Zhu, W. (2015) Enantioselective bioaccumulation of hexaconazole and its toxic effects in adult zebrafish (Danio rerio). Chemosphere. 138:798-805

Zhang, Q., Cheng, J., Xin, Q. (2015) Effects of tetracycline on developmental toxicity and molecular responses in zebrafish (Danio rerio) embryos. Ecotoxicology (London, England). 24(4):707-19

Zhou, R., Zhang, H., Wang, Z., Zhou, X., Si, J., Gan, L., Li, J., Liu, Y. (2015) The developmental toxicity and apoptosis in zebrafish eyes induced by carbon-ion irradiation. Life sciences. 139:114-22

Zhu, L., Mu, X., Wang, K., Chai, T., Yang, Y., Qiu, L., Wang, C. (2015) Cyhalofop-butyl has the potential to induce developmental toxicity, oxidative stress and apoptosis in early life stage of zebrafish (Danio rerio). Environmental pollution (Barking, Essex : 1987). 203:40-49

Brun, N.R., Christen, V., Furrer, G., Fent, K. (2014) Indium and Indium Tin Oxide Induce Endoplasmic Reticulum Stress and Oxidative Stress in Zebrafish (Danio rerio). Environmental science & technology. 48(19):11679-87

Jiang, J., Wu, S., Wu, C., An, X., Cai, L., Zhao, X. (2014) Embryonic exposure to carbendazim induces the transcription of genes related to apoptosis, immunotoxicity and endocrine disruption in zebrafish (Danio rerio). Fish & shellfish immunology. 41(2):493-500

Niu, X., Hong, J., Zheng, X., Melville, D.B., Knapik, E.W., Meng, A., Peng, J. (2014) The Nuclear Pore Complex Function of Sec13 Protein Is Required for Cell Survival during Retinal Development. The Journal of biological chemistry. 289:11971-85

Sun, L., Xin, L., Peng, Z., Jin, R., Jin, Y., Qian, H., and Fu, Z. (2014) Toxicity and enantiospecific differences of two beta-blockers, propranolol and metoprolol, in the embryos and larvae of zebrafish (Danio rerio). Environmental toxicology. 29(12):1367-78

Gioacchini, G., Valle, L.D., Benato, F., Fimia, G.M., Nardacci, R., Ciccosanti, F., Piacentini, M., Borini, A., and Carnevali, O. (2013) Interplay between autophagy and apoptosis in the development of Danio rerio follicles and the effects of a probiotic. Reproduction, fertility, and development. 25(8):1115-1125

Jin, Y., Pan, X., Limin, C., Ma, B., and Fu, Z. (2013) Embryonic exposure to cis-bifenthrin enantioselectively induces the transcription of genes related to oxidative stress, apoptosis and immunotoxicity in zebrafish (Danio rerio). Fish & shellfish immunology. 34(2):717-723

Jung, I.H., Leem, G.L., Jung, D.E., Kim, M.H., Kim, E.Y., Kim, S.H., Park, H.C., and Park, S.W. (2013) Glioma is formed by active Akt1 alone and promoted by active Rac1 in transgenic zebrafish. Neuro-Oncology. 15(3):290-304

Lin, H.J., Lee, S.H., Wu, J.L., Duann, Y.F., and Chen, J.Y. (2013) Development of Cre-loxP technology in zebrafish to study the regulation of fish reproduction. Fish physiology and biochemistry. 39(6):1525-39

Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735

Sorrells, S., Carbonneau, S., Harrington, E., Chen, A.T., Hast, B., Milash, B., Pyati, U., Major, M.B., Zhou, Y., Zon, L.I., Stewart, R.A., Look, A.T., and Jette, C. (2012) Ccdc94 Protects Cells from Ionizing Radiation by Inhibiting the Expression of p53. PLoS Genetics. 8(8):e1002922

Jin, Y., Zheng, S., and Fu, Z. (2011) Embryonic exposure to cypermethrin induces apoptosis and immunotoxicity in zebrafish (Danio rerio). Fish & shellfish immunology. 30(4-5):1049-54

Jin, Y., Zheng, S., Pu, Y., Shu, L., Sun, L., Liu, W., and Fu, Z. (2011) Cypermethrin has the potential to induce hepatic oxidative stress, DNA damage and apoptosis in adult zebrafish (Danio rerio). Chemosphere. 82(3):398-404

Deng, J., Yu, L., Liu, C., Yu, K., Shi, X., Yeung, L.W., Lam, P.K., Wu, R.S., and Zhou, B. (2009) Hexabromocyclododecane-induced developmental toxicity and apoptosis in zebrafish embryos. Aquatic toxicology (Amsterdam, Netherlands). 93(1):29-36

Stein, C., Caccamo, M., Laird, G., and Leptin, M. (2007) Conservation and divergence of gene families encoding components of innate immune response systems in the zebrafish. Genome biology. 8(11):R251

Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433

Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903

Inohara, N. and Nuñez, G. (2000) Genes with homology to mammalian apoptosis regulators identified in zebrafish. Cell death and differentiation. 7(5):509-510

Additional Citations (21):

ZFIN Staff (2023) Automated Curation of UniProt Database Links. Automated Data Submission.

ZFIN Staff (2022) Electronic Gene Ontology annotations created by ARBA machine learning models. Automated Data Submission.

ZFIN Staff (2020) Addition of links from ZFIN to Expression Atlas. Semi-automated Curation.

ZFIN Staff (2017) Curation of PANTHER Gene IDs. Automated Data Submission.

ZFIN Staff (2017) Curation of Alliance of Genome Resources Database Links. Automated Data Submission.

UniProt curators (2015) Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features.. Automated Data Submission.

Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.

ZFIN Staff (2013) Semi-automated association of ENSDARG identifiers with ZFIN genes for the ZMP project. Semi-automated Curation.

Burgess, S., and Lin, S. (2012) Viral Insertion Mutants Overwrite Data. ZFIN Direct Data Submission.

Burgess, S., and Lin, S. (2011) Viral Insertion Mutants. ZFIN Direct Data Submission.

UniProt-GOA (2011) Gene Ontology annotation based on the manual assignment of UniProtKB Subcellular Location terms in UniProtKB/Swiss-Prot entries. Manually curated data.

Gaudet, P., Livstone, M., Thomas, P., The Reference Genome Project (2010) Annotation inferences using phylogenetic trees. Automated Data Submission.

GOA curators, UniProt curators (2007) Gene Ontology annotation based on Swiss-Prot Subcellular Location vocabulary mapping. Manually curated data.

ZFIN Staff (2007) Microarray Expression to Gene Association in ZFIN. Semi-automated Curation.

ZFIN Staff (2006) Curation of Ensembl Database Links. Automated Data Submission.

ZFIN Staff (2004) ZGC Data Curation and Association in ZFIN by ZFIN Staff. Semi-automated Curation.

ZFIN Staff (2003) Curation of VEGA Database Links. Automated Data Submission.

ZFIN Staff (2003) Curation of orthology data. Manually curated data.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of UniProt Keywords with GO Terms. Automated Data Submission.

ZFIN Staff (2002) Curation of NCBI Gene Data Via Shared RNA Sequence IDs. Automated Data Submission.

ZFIN Staff (2002) Gene Ontology Annotation Through Association of InterPro Records with GO Terms. Automated Data Submission.