Stainier et al., 1996 - Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo. Development (Cambridge, England)   123:285-292

Fig. 1

Mutations affecting heart size. (A,B) wild type; (C,D) enlarged heart of vtnm201; (E,F) small heart of hasm129. No chamber organization is evident in hasm129. A, C and E are Nomarski views of living embryos and B, D and F are histological sections. The atrium is in focus in A and C and in the histological section of D. a, atrium, v, ventricle. Scale bar, 100 µm.

PHENOTYPE:
Fish:
Observed In:
Stage Range: Long-pec to Pec-fin

Fig. 2

The mutant panm313 has a reduced ventricle, as shown here at 48 hpf. (A) Nomarski view of the living embryo. (B) Histological section. The atrium appears to connect directly to the bulbus arteriosus. Scale bar, 100 µm.

Fig. 3

Two separate hearts are formed in the cardia bifida mutations. (A) wild type, ventral view; (B) milm93, ventral view; (C) milm93, histological section; all at 36 hpf. The two hearts (arrows, although one is slightly out of focus) are visible in whole embryos (B) as well as in cross sections (C). Endocardium not shown in these sections. Scale bars, 250 µm for A and B; 100 µm for C.

PHENOTYPE:
Fish:
Observed In:
Stage: Prim-25

Fig. 4

Mutations that perturb the development of the atrioventricular valves. (A,C) Wildtype sibling embryos, corresponding to (B) jekm310 and (D) m27. The atrioventricular valves are clearly visible at 96 hpf of development in the wild type. Both mutants lack those structures. a, atrium; v, ventricle. Scale bar, 100 µm.

Fig. 5

Hemorrhage mutants. Extravasation of blood in the head (arrows) in (A) bbhm292 and (B) m413. Scale bar, 250 µm.

Fig. 6

The effect of some mutations that affect heart function. (A) Atrial view of weam448, at 48 hpf. The atrium is silent and there is expansion of the cardiac jelly (arrowheads). (B) Atrial view of halm235, at 48 hpf. The ventricle is weak and the atrium is enlarged. (C) pplm340, at 48 hpf. Both chambers are dysmorphic. Scale bar, 100 µm.

Table 1 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Table 2 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Unillustrated author statements

Acknowledgments:
ZFIN wishes to thank the journal Development (Cambridge, England) for permission to reproduce figures from this article. Please note that this material may be protected by copyright.