FIGURE SUMMARY
Title

Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility

Authors
Machiela, M.J., Grünewald, T.G.P., Surdez, D., Reynaud, S., Mirabeau, O., Karlins, E., Rubio, R.A., Zaidi, S., Grossetete-Lalami, S., Ballet, S., Lapouble, E., Laurence, V., Michon, J., Pierron, G., Kovar, H., Gaspar, N., Kontny, U., González-Neira, A., Picci, P., Alonso, J., Patino-Garcia, A., Corradini, N., Bérard, P.M., Freedman, N.D., Rothman, N., Dagnall, C.L., Burdett, L., Jones, K., Manning, M., Wyatt, K., Zhou, W., Yeager, M., Cox, D.G., Hoover, R.N., Khan, J., Armstrong, G.T., Leisenring, W.M., Bhatia, S., Robison, L.L., Kulozik, A.E., Kriebel, J., Meitinger, T., Metzler, M., Hartmann, W., Strauch, K., Kirchner, T., Dirksen, U., Morton, L.M., Mirabello, L., Tucker, M.A., Tirode, F., Chanock, S.J., Delattre, O.
Source
Full text @ Nat. Commun.

Manhattan plot of meta-analysis –log10P-values for the association of each SNP with EWS risk. Association -log10 p-values for each tested genetic variant are plotted. Chromosomes are plotted sequentially across the x-axis with the scale proportional to chromosomal size. Colors are used to visualize differences in chromosome. The dotted line indicates genome-wide significance (P<5×10-8)

Conditional analysis at the 20p11.22-23 region. Overall meta-analysis –log10P-values are plotted in gray in the background. In the foreground, meta-analysis –log10p-values when the top tagging SNP is the region (rs6047482) is conditioned on is plotted in blue. A second independent signal, tagged by rs6106336, remains

Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nat. Commun.