FIGURE SUMMARY
- Title
-
An automated screening method for detecting compounds with goitrogenic activity using transgenic zebrafish embryos
- Authors
- Jarque, S., Fetter, E., Veneman, W.J., Spaink, H.P., Peravali, R., Strähle, U., Scholz, S.
- Source
- Full text @ PLoS One
Overview of the KNIME workflow that was applied to quantify tg:mcherry fluorescence in transgenic embryos. The region of the thyroid gland (tg) was selected by manually drawing a rectangle on the appropriate autofocus or Z-stack images after background removal (A, corresponding bright field image shown in B). The thyroid gland was automatically detected and converted to a label, (C) The label was overlaid onto the original image (D) and used to calculate the sum of pixels. tg–area with thyroid follicles, ba–branchial arches, m–mouth. |
Acknowledgments
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Full text @ PLoS One