Wu et al., 2018 - RIP2 Is a Critical Regulator for NLRs Signaling and MHC Antigen Presentation but Not for MAPK and PI3K/Akt Pathways. Frontiers in immunology   9:726 Full text @ Front Immunol

Fig. 1

RIP2 is critical for embryo hatching and larvae survival. (A) The images of embryos and larvae from WT and RIP2−/− zebrafish at 3 days post-fertilization (dpf). (B) The hatching rate of WT and RIP2−/− zebrafish at 2, 3, 4, and 5 dpf (n = 3, each with 48 embryos). Data represent the mean ± the SEM and were tested for statistical significance using two-tailed Student’s t-test. **p < 0.01, *p < 0.05. (C) The embryo survival curves of WT and RIP2−/− zebrafish (n = 3, each with 48 embryos). (D) The larval survival curves of WT and RIP2−/− zebrafish (n = 3, each with 40 larvae). The survival curves were compared statistically significant difference using the Log-Rank Test. (E) The hatching rate of WT and RIP2−/− zebrafish microinjected with ptGFP1 or ptGFP1-RIP2 at 3, 4, and 5 dpf (n = 2, each with 75 embryos). Data represent the mean ± the SEM, and were tested for statistical significance using two-tailed Student’s t-test. *p < 0.05. (F) The embryo survival curves of WT and RIP2−/− zebrafish microinjected with ptGFP1 or ptGFP1-RIP2 (n = 2, each with 75 embryos). The survival curves were compared statistically significant difference using the Log-Rank Test. The P-values lower than 0.001 were in red.

PHENOTYPE:
Fish:
Observed In:
Stage Range: Prim-5 to Days 7-13

Fig. 4 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Fig. 5 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Fig. 6 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Fig. 7 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

EXPRESSION / LABELING:
Genes:
Antibodies:
Fish:
Anatomical Term:
Stage Range: Long-pec to Days 7-13
PHENOTYPE:
Fish:
Observed In:
Stage Range: Long-pec to Days 7-13

Fig. 8 ZFIN is incorporating published figure images and captions as part of an ongoing project. Figures from some publications have not yet been curated, or are not available for display because of copyright restrictions.

Acknowledgments:
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Immunol