FIGURE SUMMARY
Title

Tetrahydroxystilbene glucoside isolated from Polygonum multiflorum Thunb. demonstrates osteoblast differentiation promoting activity.

Authors
Zheng, Y., Li, J., Wu, J., Yu, Y., Yao, W., Zhou, M., Tian, J., Zhang, J., Cui, L., Zeng, X., Liu, Y.
Source
Full text @ Exp. Ther. Med.

Effects of Dex and TSG on zebrafish larvae at 9 days post fertilization. (A) Ventral view of Alizarin red whole-mount preparations (magnification, ×100). Areas of calcified matrix in craniofacial skeleton are stained red, while otoliths (not bony structures) appear brown/black. Compared with the blank and vehicle (0.5% DMSO) control groups, the groups treated with 5, 10 and 20 µmol/l Dex demonstrated marked decrease in area and density of red staining. The TSG-treated groups (3.125, 6.25 and 12.5 µg/ml) presented significantly increased mineralized area and density of red staining. (B) Effects of Dex on mineralized area and IOD of mean pixel number of zebrafish larvae. #P<0.05 vs. blank group; *P<0.05 vs. DMSO control group. (C) Effects of TSG on mineralized area and IOD of mean pixel number of zebrafish larvae. #P<0.05 vs. DMSO control group; *P<0.05 vs. 10 µmol/l Dex group. Dex, dexamethasone; TSG, tetrahydroxystilbene glucoside; IOD, integrated optical density; DMSO, dimethyl sulfoxide.

Acknowledgments
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