Sredni et al., 2017 - A functional screening of the kinome identifies the Polo-like kinase 4 as a potential therapeutic target for malignant rhabdoid tumors, and possibly, other embryonal tumors of the brain. Pediatric blood & cancer   64(11) Full text @ Pediatr Blood Cancer

Fig. 5

Cytotoxic effects of CFI-400945 in vivo. (A) Comparison of the N-terminal fragment, corresponding to the kinase domain, of human PLK4 (Hs) and the zebrafish ortholog Plk4 (zf). The protein sequences are highly conserved (red: identical amino acids; blue: conserved amino acids), including identical bases involved in CFI-400945 binding sites (highlighted in green). (B) Representative phenotype of a normal zebrafish larva (top) and a zebrafish larva treated with 20 μM of CFI-400945 that developed pericardial and pronephric duct edema (arrows). (C) Data on the table corresponds to treatment of zebrafish larvae with different concentrations of CFI-400945 at 72 hr

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Pediatr Blood Cancer