FIGURE SUMMARY
- Title
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Stem cell cultures derived from pediatric brain tumors accurately model the originating tumors
- Authors
- Wenger, A., Larsson, S., Danielsson, A., Elbæk, K.J., Kettunen, P., Tisell, M., Sabel, M., Lannering, B., Nordborg, C., Schepke, E., Carén, H.
- Source
- Full text @ Oncotarget
The pediatric tumor cells are tumorigenic when injected into the brains of immunodeficient mice and zebrafish. A. Mouse brain orthotopically injected with BPC-C8 (1*105 cells), stained with H&E (top) and human nestin (bottom) show massive infiltration of the injected hemisphere. B. Survival curve of all cell lines injected in mice; BPC-A7, BPC-C3 and BPC-C8. C. RFP-labelled BPC-A7 cells (left), enlarged picture (right), injected into the brain of two days old zebrafish show invasive growth into the brain. D. Survival curve of adult zebrafish injected with BPC-A7 and neural stem (NS) cells. |
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Full text @ Oncotarget