FIGURE SUMMARY
Title

Oncometabolite succinate promotes angiogenesis by upregulating VEGF expression through GPR91-mediated STAT3 and ERK activation

Authors
Mu, X., Zhao, T., Xu, C., Shi, W., Geng, B., Shen, J., Zhang, C., Pan, J., Yang, J., Hu, S., Lv, Y., Wen, H., You, Q.
Source
Full text @ Oncotarget
Fig. 3

Succinate promotes vessel formation in the zebrafish embryo. A. Effect of succinate on angiogenesis was evaluated in zebrafish embryos. Transgenic (flk1: GFP) zebrafish embryos were picked out and distributed into a 24-well microplate (9 embryos/well), and pre-treated with 0.2 μg/mL PTK787 (VEGFR inhibitor, Sigma). Then, various concentration of succinate (0, 100, 200, 400, 800 μM) or 10 ng/mL of VEGF165 were added to the culture for twenty-four hours. Representative photographs are listed to show the subintestinal vessels (SIVs) indicated by white arrow. B, C. Quantitative analysis of the overall length of zebrafish SIVs are shown. Data are presented as mean ±SD.*p<0.05 and **p<0.01 versus PBS control.
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Oncotarget
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