FIGURE SUMMARY
- Title
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Irisin Induces Angiogenesis in Human Umbilical Vein Endothelial Cells In Vitro and in Zebrafish Embryos In Vivo via Activation of the ERK Signaling Pathway
- Authors
- Wu, F., Song, H., Zhang, Y., Zhang, Y., Mu, Q., Jiang, M., Wang, F., Zhang, W., Li, L., Li, H., Wang, Y., Zhang, M., Li, S., Yang, L., Meng, Y., Tang, D.
- Source
- Full text @ PLoS One
Irisin restored chemically-induced ISV angiogenesis impairment in zebrafish. (A) Lateral view of control embryos and embryos treated with 6 uM of PTK787 for 24 h. Embryos treated with 20, 50, and 100 nM of irisin after pretreatment with PTK787. ISVs are indicated by the white arrows. (B) Quantification of total length of ISVs induced by irisin (n = 6–8). Data are presented as the mean± SE. **P< 0.01 vs. PTK787 treated group, determined by unpaired two-tailed Student’s t-test. |
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Full text @ PLoS One