| ZFIN ID: ZDB-EXP-210730-9 |
Experiment Conditions Description: chemical treatment by environment: tiagabine, surgical manipulation: optic tectum
| chemical treatment by environment: tiagabine |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | tiagabine |
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| Synonyms: | (-)-(R)-1-(4,4-bis(3-methyl-2-thienyl)-3-butenyl)nipecotic acid, (-)-(R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]nipecotic acid, (3R)-1-[4,4-bis(3-methyl-2-thienyl)but-3-en-1-yl]piperidine-3-carboxylic acid, (R)-(-)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]nipecotic acid, (R)-tiagabine, tiagabina, tiagabine, tiagabinum |
| Definition: | A piperidinemonocarboxylic acid that is (R)-nipecotic acid in which the hydrogen attached to the nitrogen has been replaced by a 1,1-bis(3-methyl-2-thienyl)but-1-en-4-yl group. A GABA reuptake inhibitor, it is used (generally as the hydrochloride salt) for the treatment of epilepsy. |
| Ontology: | ChEBI [CHEBI:9586] ( EBI ) |
| surgical manipulation: optic tectum |
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| Name: | surgical manipulation |
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| Synonyms: | |
| Definition: | Experimental condition that involves manual or instrumental techniques to alter anatomical structures. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000176] |
| Name: | optic tectum |
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| Synonyms: | dorsal midbrain, mesencephalic tectum, tectal lobe, tectum, tectum opticum |
| Definition: | Multi-tissue structure that is the dorsal part of the midbrain and develops from the alar plate and is the most complex layered structure in the zebrafish brain. |
| Ontology: | Anatomy Ontology [ZFA:0000445] |
| Publication: | Herzog et al., 2020 |
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