| ZFIN ID: ZDB-EXP-191127-7 |
Experiment Conditions Description: cancer xenotransplantation, chemical treatment by environment: tyrosine kinase inhibitor, chemical treatment by environment: paclitaxel
| cancer xenotransplantation |
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| Name: | cancer xenotransplantation |
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| Synonyms: | |
| Definition: | Xenotransplantation condition in which cancer cells are injected or grafted into the zebrafish. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000236] |
| chemical treatment by environment: tyrosine kinase inhibitor |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | tyrosine kinase inhibitor |
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| Synonyms: | protein tyrosine kinase inhibitor, protein tyrosine kinase inhibitors, TKI inhibitor, TKI inhibitors, tyrosine kinase inhibitors, tyrphostin, tyrphostins |
| Definition: | Any protein kinase inhibitor that interferes with the action of tyrosine kinase. |
| Ontology: | ChEBI [CHEBI:38637] ( EBI ) |
| chemical treatment by environment: paclitaxel |
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| Name: | chemical treatment by environment |
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| Synonyms: | |
| Definition: | Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water. |
| Ontology: | Zebrafish Environment Condition Ontology [ZECO:0000238] |
| Name: | paclitaxel |
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| Synonyms: | (2aR-(2aalpha,4beta,4abeta,6beta,9alpha(alpha R*,betaS*),11alpha,12alpha,12balpha))-beta-(Benzoylamino)-alpha-hydroxybenzenepropanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramet, 4alpha,10beta-bis(acetyloxy)-13alpha-[(2S,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyloxy]-1,7beta-dihydroxy-9-oxo-5beta,20-epoxytax-11-en-2alpha-yl benzoate, 5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine, Paclitaxel, TAXOL, Taxol A |
| Definition: | A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark. |
| Ontology: | ChEBI [CHEBI:45863] ( EBI ) |
| Publication: | Xu et al., 2019 |
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