Community Action Needed: Please respond to the NIH RFI
ZFIN ID: ZDB-EXP-171017-8
Experiment Conditions Description: chemical treatment by environment: aphidicolin, chemical treatment by environment: hydroxyurea
chemical treatment by environment: aphidicolin
Name: chemical treatment by environment
Synonyms:
Definition: Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000238]
Name: aphidicolin
Synonyms: (3alpha,4alpha,5alpha,17alpha)-3,17-dihydroxy-4-methyl-9,15-cyclo-C,18-dinor-14,15-secoandrostane-4,17-dimethanol, (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-4,9-bis(hydroxymethyl)-4,11b-dimethyltetradecahydro-8,11a-methanocyclohepta[a]naphthalene-3,9-diol, Aphidicolin, aphidocolin
Definition: A tetracyclic diterpenoid that has an tetradecahydro-8,11a-methanocyclohepta[a]naphthalene skeleton with two hydroxymethyl substituents at positions 4 and 9, two methyl substituents at positions 4 and 11b and two hydroxy substituents at positions 3 and 9. An antibiotic with antiviral and antimitotical properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication.
Ontology: Chebi [CHEBI:2766]
chemical treatment by environment: hydroxyurea
Name: chemical treatment by environment
Synonyms:
Definition: Chemical treatment condition in which the chemical is introduced through the environment. For zebrafish this is the tank water.
Ontology: Zebrafish Environment Condition Ontology [ZECO:0000238]
Name: hydroxyurea
Synonyms: carbamohydroxamic acid, carbamohydroximic acid, carbamoyl oxime, carbamyl hydroxamate, hidroxicarbamida, hydrea, Hydroxycarbamid, Hydroxycarbamide, hydroxycarbamidum, Hydroxyharnstoff, Hydroxyurea, N-carbamoylhydroxylamine, N-hydroxyurea, oxyurea
Definition: A member of the class of ureas that is urea in which one of the hydrogens is replaced by a hydroxy group. An antineoplastic used in the treatment of chronic myeloid leukaemia as well as for sickle-cell disease.
Ontology: Chebi [CHEBI:44423]
Publication: Naylor et al., 2017