PUBLICATION

Midline structures and central nervous system coordinates in zebrafish

Authors
Hatta, K. and Kimmel, C.B.
ID
ZDB-PUB-961014-419
Date
1993
Source
Perspectives on developmental neurobiology   1: 257-268 (Review)
Registered Authors
Hatta, Kohei, Kimmel, Charles B.
Keywords
none
MeSH Terms
  • Animals
  • Axons/physiology
  • Central Nervous System/abnormalities
  • Central Nervous System/embryology*
  • Embryo, Nonmammalian/abnormalities
  • Embryo, Nonmammalian/physiology
  • Embryo, Nonmammalian/ultrastructure
  • Embryonic Induction
  • Embryonic and Fetal Development
  • Gene Expression Regulation
  • Genes, Homeobox
  • Germ Layers/ultrastructure
  • Homeodomain Proteins*
  • Morphogenesis
  • Mutation
  • Nerve Tissue Proteins/genetics
  • Nerve Tissue Proteins/physiology
  • Notochord/embryology
  • Signal Transduction
  • Zebrafish/embryology*
  • Zebrafish/genetics
PubMed
7916258
Abstract
The embryonic zebrafish provides a relatively simple and accessible experimental system for understanding the underlying Bauplan of a vertebrate central nervous system (CNS) and for uncovering interactions critical for patterning. We show that features of CNS organization in normal, mutant, and developmentally ventralized zebrafish embryos can be explained by a three-axis hypothesis: Specifications occur according to position relative to coordinates along the anterior-posterior, dorsal-ventral, and luminal-pial axes of the neural tube. Midline tissues may be responsible for directly establishing the dorsal-ventral coordinates, but may only be indirectly involved in patterning along the anterior- posterior axis.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping