ZFIN ID: ZDB-PUB-191226-20
A 45-years journey within the reproductive brain of fish
Kah, O.
Date: 2019
Source: General and comparative endocrinology   288: 113370 (Other)
Registered Authors: Kah, Olivier
Keywords: GABA, GnRH, aromatase, cyp19a1b,, dopamine, estradiol, estrogen receptor, glucocorticoid, goldfish, hypothalamus, neuropeptide Y, pituitary, rainbow trout, reproduction, sea bass, serotonin, teleosts fish, zebrafish
MeSH Terms:
  • Animals
  • Brain/metabolism
  • Brain/physiology*
  • Developmental Biology*/history
  • Endocrine Disruptors/pharmacology
  • Endocrinology*/history
  • Estrogens/pharmacology
  • France
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Oncorhynchus mykiss/physiology
  • Reproduction/physiology*
  • Zebrafish*/physiology
  • Zebrafish Proteins/metabolism
PubMed: 31870884 Full text @ Gen. Comp. Endocrinol.
This article summarizes the scientific carrier of Dr. Olivier Kah, currently emeritus research director at the National Center of Scientific Research (CNRS) in France. Olivier Kah partly grew up in Africa where he developed a strong interest for animals. He studied biology in Paris and Bordeaux. He next received his PhD at the University of Bordeaux en 1978 and his Doctor of Science degree in 1983. He joined the CNRS in 1979 until his retirement in 2016. Olivier Kah dedicated his carrier to the study of reproduction, in particular to the roles of brain neuropeptides and neurotransmitters in the control of the reproductive axis in vertebrates, mostly fish. More specifically, Olivier Kah was specialized in the use of morphofunctional techniques that he implemented to the study of the organization of the hypothalamo-pituitary complex. He was also interested in the steroid feedback and studied intensively the expression and regulation of estrogen and glucocorticoid receptors in the rainbow trout and the zebrafish. In the last 10 years, Olivier Kah's team focused on the expression and regulation of aromatase in the brain and established that aromatase expression is restricted to a unique brain cell type, the radial glial cells, which serve as progenitors during the entire life of fish. He is also interested in the impact of endocrine disruptors using the zebrafish as a model and recently his team has developed an exquisitely sensitive in vivo assay to screen estrogenic chemicals on zebrafish embryos.