PUBLICATION
Polysiphonia japonica Extract Attenuates Palmitate-Induced Toxicity and Enhances Insulin Secretion in Pancreatic Beta-Cells
- Authors
- Cha, S.H., Kim, H.S., Hwang, Y., Jeon, Y.J., Jun, H.S.
- ID
- ZDB-PUB-181205-5
- Date
- 2018
- Source
- Oxidative medicine and cellular longevity 2018: 4973851 (Journal)
- Registered Authors
- Keywords
- none
- MeSH Terms
-
- Animals
- Cell Survival
- Cells, Cultured
- Glucose/metabolism
- Insulin Secretion/drug effects*
- Insulin-Secreting Cells/drug effects
- Insulin-Secreting Cells/metabolism*
- Insulin-Secreting Cells/pathology
- Male
- Mice
- Mice, Inbred C57BL
- Palmitates/toxicity*
- Plant Extracts/pharmacology*
- Rats
- Rhodophyta/chemistry*
- Zebrafish
- PubMed
- 30510621 Full text @ Oxid Med Cell Longev
Citation
Cha, S.H., Kim, H.S., Hwang, Y., Jeon, Y.J., Jun, H.S. (2018) Polysiphonia japonica Extract Attenuates Palmitate-Induced Toxicity and Enhances Insulin Secretion in Pancreatic Beta-Cells. Oxidative medicine and cellular longevity. 2018:4973851.
Abstract
Beta-cell loss is a major cause of the pathogenesis of diabetes. Elevated levels of free fatty acids may contribute to the loss of β-cells. Using a transgenic zebrafish, we screened ~50 seaweed crude extracts to identify materials that protect β-cells from free fatty acid damage. We found that an extract of the red seaweed Polysiphonia japonica (PJE) had a β-cell protective effect. We examined the protective effect of PJE on palmitate-induced damage in β-cells. PJE was found to preserve cell viability and glucose-induced insulin secretion in a pancreatic β-cell line, Ins-1, treated with palmitate. Additionally, PJE prevented palmitate-induced insulin secretion dysfunction in zebrafish embryos and mouse primary islets and improved insulin secretion in β-cells against palmitate treatment. These findings suggest that PJE protects pancreatic β-cells from palmitate-induced damage. PJE may be a potential therapeutic functional food for diabetes.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping