FIGURE

Figure 9

ID

ZDB-FIG-250329-72

Publication

Cho et al., 2025 - Synergistic Efficacy of Policosanol (Raydel^®) and Banaba Leaf Extract to Treat Hyperglycemia and Dyslipidemia in Streptozotocin-Induced Diabetic and Hyperlipidemic Zebrafish (Danio rerio): Protection of Liver and Kidney with Enhanced Tissue Regeneration

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Figure 9

Effect of banaba leaf extract and policosanol (alone or in combination) on the kidney histology of the streptozotocin-treated hyperlipidemia zebrafish (n = 3). (A) Hematoxylin and eosin (H&E) staining. PT and DT represent the proximal and distal tubules; the blue and red arrows describe the enlarged tubular lumen and luminal debris. (B) Dihydroethidium (DHE) and (C) acridine orange (AO) fluorescent staining were used to determine ROS and apoptosis, respectively. (D) Senescence-associated β-galactosidase (SA-β-gal) staining. (E,F) illustrate the quantification of DHE and AO fluorescence intensity, respectively. (G) Percentage quantification of the SA-β-gal-positive area. Abbreviations: HCD (high cholesterol diet), STZ (streptozotocin), BNB (banaba), and PCO (policosanol). The symbols *, **, and *** underline the statistical significance at p < 0.05, p < 0.01, and p < 0.001, respectively, vs. the HCD+STZ group. † and †† indicate statistical significance at p < 0.05 and p < 0.01 vs. the BNB+PCO group.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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