PUBLICATION

Centromere-linkage analysis and consolidation of the zebrafish genetic map

Authors
Johnson, S.L., Gates, M.A., Johnson, M., Talbot, W.S., Horne, S., Baik, K., Rude, S., Wong, J.R., and Postlethwait, J.H.
ID
ZDB-PUB-961014-497
Date
1996
Source
Genetics   142: 1277-1288 (Journal)
Registered Authors
Gates, Michael A., Horne-Badovinac, Sally, Johnson, Stephen L., Postlethwait, John H., Talbot, William S.
Keywords
none
MeSH Terms
  • Animals
  • Base Sequence
  • Centromere*
  • Chromosome Mapping*
  • DNA Primers
  • Genetic Linkage*
  • Genetic Markers
  • Molecular Sequence Data
  • Polymorphism, Genetic
  • Zebrafish/genetics*
PubMed
8846904 Full text @ Genetics
Abstract
The ease of isolating mutations in zebrafish will contribute to an understanding of a variety of processes common to all vertebrates. To facilitate genetic analysis of such mutations, we have identified DNA polymorphisms closely linked to each of the 25 centromeres of zebrafish, placed centromeres on the linkage map, increased the number of mapped PCR-based markers to 652, and consolidated the number of linkage groups to the number of chromosomes. This work makes possible centromere-linkage analysis, a novel, rapid method to assign mutations to a specific linkage group using half- tetrads.
Genes / Markers
Figures
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Antibodies
Orthology
Engineered Foreign Genes
Mapping