PUBLICATION
Directional cell migration establishes the axes of planar polarity in the posterior lateral-line organ of the zebrafish
- Authors
- Lopez-Schier, H., Starr, C.J., Kappler, J.A., Kollmar, R., and Hudspeth, A.J.
- ID
- ZDB-PUB-040916-1
- Date
- 2004
- Source
- Developmental Cell 7(3): 401-412 (Journal)
- Registered Authors
- Hudspeth, A.J. (Jim), Kappler, James A., Kollmar, Richard, Lopez-Schier, Hernan, Starr, Catherine J.
- Keywords
- none
- MeSH Terms
-
- Animals
- Body Patterning
- Cell Division
- Cell Line
- Cell Lineage
- Cell Movement
- DNA/chemistry
- Epithelium/embryology*
- Fishes
- Hair Cells, Auditory/embryology*
- Immunohistochemistry
- Lasers
- Microscopy, Confocal
- Microscopy, Fluorescence
- Mutation
- Oligonucleotides/chemistry
- Sense Organs/embryology
- Zebrafish
- PubMed
- 15363414 Full text @ Dev. Cell
Citation
Lopez-Schier, H., Starr, C.J., Kappler, J.A., Kollmar, R., and Hudspeth, A.J. (2004) Directional cell migration establishes the axes of planar polarity in the posterior lateral-line organ of the zebrafish. Developmental Cell. 7(3):401-412.
Abstract
The proper orientation of mechanosensory hair cells along the lateral-line organ of a fish or amphibian is essential for the animal's ability to sense directional water movements. Within the sensory epithelium, hair cells are polarized in a stereotyped manner, but the mechanisms that control their alignment relative to the body axes are unknown. We have found, however, that neuromasts can be oriented either parallel or perpendicular to the anteroposterior body axis. By characterizing the strauss mutant zebrafish line and by tracking labeled cells, we have demonstrated that neuromasts of these two orientations originate from, respectively, the first and second primordia. Furthermore, altering the migratory pathway of a primordium reorients a neuromast's axis of planar polarity. We propose that the global orientation of hair cells relative to the body axes is established through an interaction between directional movement by primordial cells and the timing of neuromast maturation.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping