PUBLICATION
Platelet-derived growth factor receptor alpha (pdgfr-alpha) gene in zebrafish embryonic development
- Authors
- Liu, L., Chong, S.W., Balasubramaniyan, N.V., Korzh, V., and Ge, R.
- ID
- ZDB-PUB-020730-8
- Date
- 2002
- Source
- Mechanisms of Development 116(1-2): 227-230 (Journal)
- Registered Authors
- Balasubramaniyan, Nataraja, Chong, Shang Wei, Korzh, Vladimir, Liu, Lihui
- Keywords
- pdgfr-a; zebratish; neurogenesis; somitogenesis; Kupffer's vesicle; neural crest cells (NCC
- MeSH Terms
-
- Animals
- Cloning, Molecular
- DNA, Complementary/genetics
- Gene Expression Regulation, Developmental
- In Situ Hybridization
- Neural Crest/embryology
- Neural Crest/metabolism
- Phylogeny
- RNA, Messenger/genetics
- RNA, Messenger/metabolism
- Receptor, Platelet-Derived Growth Factor alpha/genetics*
- Somites/metabolism
- Zebrafish/embryology*
- Zebrafish/genetics*
- PubMed
- 12128230 Full text @ Mech. Dev.
Citation
Liu, L., Chong, S.W., Balasubramaniyan, N.V., Korzh, V., and Ge, R. (2002) Platelet-derived growth factor receptor alpha (pdgfr-alpha) gene in zebrafish embryonic development. Mechanisms of Development. 116(1-2):227-230.
Abstract
Here we present the cloning of a full-length zebrafish pdgfr-alpha cDNA as well as the expression of this gene during zebrafish embryogenesis. We show that zebrafish pdgfr-alpha mRNA is present at high levels in the fertilized egg as well as in all embryonic cells up to the end of gastrulation. Spatially restricted expression of the gene started after the onset of segmentation and is mainly localized in premigratory neural crest cells, the placodes, the anterior paraxial cells of somites and the adaxial cells of the tailbud. Transient expression of this gene was also detected in the early Kupffer's vesicle, a teleost-specific structure. Expression of the zebrafish pdgfr-alpha is both conserved as well as diverged comparing to that of other vertebrate species.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping