ZFIN Person: Sive, Hazel

ZFIN ID: ZDB-PERS-960805-521

Sive, Hazel

Email:	sive@wi.mit.edu
URL:	http://web.wi.mit.edu/sive/pub/home.html
Affiliation:	Hazel Sive Lab
Address:	Whitehead Institute for Biomedical Research 9 Cambridge Center Cambridge, MA 02142 USA
Country:	United States
Phone:	(617) 258-8242
Fax:	(617) 258-5578
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

Our lab is investigating the mechanisms of neural induction and patterning along the anteroposterior axis of zebrafish and Xenopus embryos. We are applying several approaches to this question, including molecular and classical genetics, and experimental embryology.

PUBLICATIONS

Tomasello, D.L., Kim, J.L., Khodour, Y., McCammon, J.M., Mitalipova, M., Jaenisch, R., Futerman, A.H., Sive, H. (2021) 16pdel lipid changes in iPSC-derived neurons and function of FAM57B in lipid metabolism and synaptogenesis. iScience. 25:103551

Tomasello, D.L., Sive, H. (2020) Noninvasive Multielectrode Array for Brain and Spinal Cord Local Field Potential Recordings from Live Zebrafish Larvae. Zebrafish. 17(4):271-277

Gutzman, J.H., Graeden, E., Brachmann, I., Yamazoe, S., Chen, J.K., Sive, H. (2018) Basal constriction during midbrain-hindbrain boundary morphogenesis is mediated by Wnt5b and focal adhesion kinase. Biology Open. 7(11):

Chen, G.R., Sive, H., Bartel, D.P. (2017) A Seed Mismatch Enhances Argonaute2-Catalyzed Cleavage and Partially Rescues Severely Impaired Cleavage Found in Fish. Molecular Cell. 68:1095-1107.e5

McCammon, J.M., Blaker-Lee, A., Chen, X., Sive, H. (2017) The 16p11.2 homologs fam57ba and doc2a generate certain brain and body phenotypes. Human molecular genetics. 26:3699-3712

Carter, B.S., Cortés-Campos, C., Chen, X., McCammon, J.M., Sive, H.L. (2017) Validation of Protein Knockout in Mutant Zebrafish Lines Using In Vitro Translation Assays. Zebrafish. 14(1):73-76

Fame, R.M., Chang, J.T., Hong, A., Aponte-Santiago, N.A., Sive, H. (2016) Directional cerebrospinal fluid movement between brain ventricles in larval zebrafish. Fluids and barriers of the CNS. 13:11

Chang, J.T., Lehtinen, M.K., Sive, H. (2016) Zebrafish cerebrospinal fluid mediates cell survival through a retinoid signaling pathway. Developmental Neurobiology. 76(1):75-92

McCammon, J.M., Sive, H. (2015) Challenges in understanding psychiatric disorders and developing therapeutics: a role for zebrafish. Disease models & mechanisms. 8:647-56

McCammon, J.M., Sive, H. (2015) Addressing the Genetics of Human Mental Health Disorders in Model Organisms. Annual review of genomics and human genetics. 16:173-97

Jacox, L., Sindelka, R., Chen, J., Rothman, A., Dickinson, A., Sive, H. (2014) The Extreme Anterior Domain Is an Essential Craniofacial Organizer Acting through Kinin-Kallikrein Signaling. Cell Reports. 8(2):596-609

Subtelny, A.O., Eichhorn, S.W., Chen, G.R., Sive, H., and Bartel, D.P. (2014) Poly(A)-tail profiling reveals an embryonic switch in translational control. Nature. 508(7494):66-71

Chang, J.T., and Sive, H. (2012) Manual drainage of the zebrafish embryonic brain ventricles. Journal of visualized experiments : JoVE. (70):e4243

Blaker-Lee, A., Gupta, S., McCammon, J.M., De Rienzo, G., and Sive, H. (2012) Zebrafish homologs of 16p11.2, a genomic region associated with brain disorders, are active during brain development, and include two deletion dosage sensor genes. Disease models & mechanisms. 5(6):834-851

Chang, J.T., and Sive, H. (2012) An assay for permeability of the zebrafish embryonic neuroepithelium. Journal of visualized experiments : JoVE. (68):e4242

Ulitsky, I., Shkumatava, A., Jan, C., Subtelny, A.O., Koppstein, D., Bell, G., Sive, H., and Bartel, D. (2012) Extensive alternative polyadenylation during zebrafish development. Genome research. 22(10):2054-2066

De Rienzo, G., Gutzman, J.H., and Sive, H. (2012) Efficient shRNA-Mediated Inhibition of Gene Expression in Zebrafish. Zebrafish. 9(3):97-107

Ulitsky, I., Shkumatava, A., Jan, C.H., Sive, H., and Bartel, D.P. (2011) Conserved Function of lincRNAs in Vertebrate Embryonic Development despite Rapid Sequence Evolution. Cell. 147(7):1537-1550

De Rienzo, G., Bishop, J.A., Mao, Y., Pan, L., Ma, T.P., Moens, C.B., Tsai, L.H., and Sive, H. (2011) Disc1 regulates both β-catenin-mediated and noncanonical Wnt signaling during vertebrate embryogenesis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 25(12):4184-97

Singh, K.K., De Rienzo, G., Drane, L., Mao, Y., Flood, Z., Madison, J., Ferreira, M., Bergen, S., King, C., Sklar, P., Sive, H., and Tsai, L.H. (2011) Common DISC1 Polymorphisms Disrupt Wnt/GSK3β Signaling and Brain Development. Neuron. 72(4):545-558

Sive, H. (2011) Keeping two animal systems in one lab - a frog plus fish case study. Methods in molecular biology (Clifton, N.J.). 770:571-578

Gutzman, J.H., and Sive, H. (2010) Epithelial relaxation mediated by the myosin phosphatase regulator Mypt1 is required for brain ventricle lumen expansion and hindbrain morphogenesis. Development (Cambridge, England). 137(5):795-804

Gutzman, J.H., and Sive, H. (2009) Zebrafish brain ventricle injection. Journal of visualized experiments : JoVE. (26)

Graeden, E., and Sive, H. (2009) Live imaging of the zebrafish embryonic brain by confocal microscopy. Journal of visualized experiments : JoVE. (26):1217

Shkumatava, A., Stark, A., Sive, H., and Bartel, D.P. (2009) Coherent but overlapping expression of microRNAs and their targets during vertebrate development. Genes & Development. 23(4):466-481

Lowery, L.A., De Rienzo, G., Gutzman, J.H., and Sive, H. (2009) Characterization and Classification of Zebrafish Brain Morphology Mutants. The Anatomical record. 292(1):94-106

Gutzman, J.H., Graeden, E.G., Lowery, L.A., Holley, H.S., and Sive, H. (2008) Formation of the zebrafish midbrain-hindbrain boundary constriction requires laminin-dependent basal constriction. Mechanisms of Development. 125(11-12):974-983

Lowery, L.A., Rubin, J., and Sive, H. (2007) whitesnake/sfpq is required for cell survival and neuronal development in the zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 236(5):1347-1357

Sive, H., Mueller, T., Wullimann, M.F., Kuwada, J.Y., Moorman, S.J., Haendel, M.A. (2006) ZFIN Anatomy Working Group: Nervous System. Manually curated data.

Wardle, F.C., Odom, D.T., Bell, G.W., Yuan, B., Danford, T.W., Wiellette, E.L., Herbolsheimer, E., Sive, H.L., Young, R.A., and Smith, J.C. (2006) Zebrafish promoter microarrays identify actively transcribed embryonic genes. Genome biology. 7(8):R71

Lowery, L.A., and Sive, H. (2005) Initial formation of zebrafish brain ventricles occurs independently of circulation and requires the nagie oko and snakehead/atp1a1a.1 gene products. Development (Cambridge, England). 132(9):2057-2067

Sagerström, C.G., Gammill, L.S., Veale, R., and Sive, H. (2005) Specification of the enveloping layer and lack of autoneuralization in zebrafish embryonic explants. Developmental Dynamics : an official publication of the American Association of Anatomists. 232(1):85-97

Wiellette, E., Grinblat, Y., Austen, M., Hirsinger, E., Amsterdam, A., Walker, C., Westerfield, M., and Sive, H. (2004) Combined haploid and insertional mutation screen in the zebrafish. Genesis (New York, N.Y. : 2000). 40(4):231-240

Lowery, L.A., and Sive, H. (2004) Strategies of vertebrate neurulation and a re-evaluation of teleost neural tube formation. Mechanisms of Development. 121(10):1189-1197

Hoyle, J., Tang, Y.P., Wiellette, E.L., Wardle, F.C., and Sive, H. (2004) nlz Gene family is required for hindbrain patterning in the zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 229(4):835-846

Wiellette, E.L., and Sive, H. (2004) Early requirement for fgf8 function during hindbrain pattern formation in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 229(2):393-399

Tropepe, V. and Sive, H.L. (2003) Can zebrafish be used as a model to study the neurodevelopmental causes of autism?. Genes, brain, and behavior. 2(5):268-281

Wiellette, E.L. and Sive, H. (2003) vhnf1 and Fgf signals synergize to specify rhombomere identity in the zebrafish hindbrain. Development (Cambridge, England). 130(16):3821-3829

Grinblat, Y. and Sive, H. (2001) zic gene expression marks anteroposterior pattern in the presumptive neurectoderm of the zebrafish gastrula. Developmental Dynamics : an official publication of the American Association of Anatomists. 222(4):688-693

Sagerström, C.G., Kao, B.A., Lane, M.E., and Sive, H. (2001) Isolation and characterization of posteriorly restricted genes in the zebrafish gastrula. Developmental Dynamics : an official publication of the American Association of Anatomists. 220(4):402-408

Wiellette, E., Grinblat, Y., Austen, M., Hopkins, N., and Sive, H. (2001) An insertional screen for identification of genes required for neural induction and patterning in the zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 15(5):A1071

Grinblat, Y., Lane, M.E., Sagerström, C., and Sive, H. (1999) Analysis of zebrafish development using explant culture assays. In The Zebrafish: Biology. H.W. Detrich, L.I. Zon, and M. Westerfield, eds. Methods Cell Biol.. 59:127-156

Grinblat, Y., Gamse, J., Patel, M., and Sive, H. (1998) Determination of the zebrafish forebrain: induction and patterning. Development (Cambridge, England). 125:4403-4416

Sagerström, C.G., Grinblat, Y., and Sive, H. (1996) Anteroposterior patterning in the zebrafish, Danio rerio: an explant assay reveals inductive and suppressive cell interactions. Development (Cambridge, England). 122:1873-1883

NON-ZEBRAFISH PUBLICATIONS