Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-960805-319
Larhammar, Dan
Larhammar Lab
Department of Neuroscience
Unit of Pharmacology
Uppsala University
Box 593
Uppsala, S-75124
Sweden
Phone: 46-18-4714173 Email: dan.larhammar@neuro.uu.se
FAX: 46-18-511540 URL: http://www.anst.uu.se/dla05000/
Biography and Research Interests:

Professor of molecular cell biology at Uppsala University since 1994.
For CV and complete list of publications, see http://www.bmc.uu.se/~danl/

Research interests:
- Evolution of neuropeptide Y and its receptors: gene duplications and molecular coevolution of peptide ligands and receptors during vertebrate evolution.
- Physiology and molecular pharmacology of the neuropeptide Y system with particular focus on roles in appetite regulation.
- Evolution of gene families in vertebrates, particularly neuronal and endocrine gene families such as peptide genes, receptor genes, ion channels, etc.

Publications:
Larsson, T.A., Tay, B.H., Sundström, G., Fredriksson, R., Brenner, S., Larhammar, D., and Venkatesh, B. (2009) Neuropeptide Y-family peptides and receptors in the elephant shark, Callorhinchus milii confirm gene duplications before the gnathostome radiation. Genomics. 93(3):254-260
Ocampo Daza, D., Sundström, G., Larsson, T.A., and Larhammar, D. (2009) Evolution of the growth hormone-prolactin-somatolactin system in relation to vertebrate tetraploidizations. Ann. N.Y. Acad. Sci.. 1163:491-493
Dreborg, S., Sundström, G., Larsson, T.A., and Larhammar, D. (2008) Evolution of vertebrate opioid receptors. Proc. Natl. Acad. Sci. USA. 105(40):15487-15492
Salaneck, E., Larsson, T.A., Larson, E.T., and Larhammar, D. (2008) Birth and death of neuropeptide Y receptor genes in relation to the teleost fish tetraploidization. Gene. 409(1-2):61-71
Sundstrom, G., Larsson, T.A., and Larhammar, D. (2008) Phylogenetic and chromosomal analyses of multiple gene families syntenic with vertebrate Hox clusters. BMC Evol. Biol.. 8(1):254
Sundström, G., Larsson, T.A., Brenner, S., Venkatesh, B., and Larhammar, D. (2008) Evolution of the neuropeptide Y family: New genes by chromosome duplications in early vertebrates and in teleost fishes. Gen. Comp. Endocrinol.. 155(3):705-716
Bromee, T., Venkatesh, B., Brenner, S., Postlethwait, J.H., Yan, Y.L., and Larhammar, D. (2006) Uneven evolutionary rates of bradykinin B1 and B2 receptors in vertebrate lineages. Gene. 373:100-108
Larsson, T.A., Larson, E.T., Fredriksson, R., Conlon, J.M., and Larhammar, D. (2006) Characterization of NPY receptor subtypes Y2 and Y7 in rainbow trout Oncorhynchus mykiss. Peptides. 27(6):1320-1327
Bromée, T., Conlon, J.M., and Larhammar, D. (2005) Bradykinin Receptors in the Zebrafish (Danio rerio). Ann. N.Y. Acad. Sci.. 1040:246-248
Conlon, J.M., and Larhammar, D. (2005) The evolution of neuroendocrine peptides. Gen. Comp. Endocrinol.. 142(1-2):53-9
Fredriksson, R., Sjodin, P., Larson, E.T., Conlon, J.M., and Larhammar, D. (2005) Cloning and characterization of a zebrafish Y2 receptor. Regul. Pept.. 133(1-3):32-40
Larsson, T.A., Olsson, F., Sundström, G., Brenner, S., Venkatesh, B., and Larhammar, D. (2005) Pufferfish and Zebrafish Have Five Distinct NPY Receptor Subtypes, but Have Lost Appetite Receptors Y1 and Y5. Ann. N.Y. Acad. Sci.. 1040:375-377
Mathieu, M., Trombino, S., Argenton, F., Larhammar, D., and Vallarino, M. (2005) Developmental Expression of NPY/PYY Receptors zYb and zYc in Zebrafish. Ann. N.Y. Acad. Sci.. 1040:399-401
Salaneck, E., Larson, E.T., Larsson, T.A., and Larhammar, D. (2005) Effects of a teleost tetraploidization on neuropeptide y receptor gene repertoire in ray-finned fishes. Ann. N.Y. Acad. Sci.. 1040:457-459
Sundström, G., Larsson, T.A., Brenner, S., Venkatesh, B., and Larhammar, D. (2005) Ray-Fin Fish Tetraploidization Gave Rise to Pufferfish Duplicates of NPY and PYY, but Zebrafish NPY Duplicate Was Lost. Ann. N.Y. Acad. Sci.. 1040:476-478
Fredriksson, R., Larson E.T., Yan, Y.-L., Postlethwait, J.H., and Larhammar, D. (2004) Novel neuropeptide Y Y2-like receptor subtype in zebrafish and frogs supports early vertebrate chromosome duplications. J. Mol. Evol.. 58(1):106-114
Larhammar, D., and Salaneck, E. (2004) Molecular evolution of NPY receptor subtypes. Neuropeptides. 38(4):141-151
Ruuskanen, J., Xhaard, H., Marjamäki, A., Salaneck, E., Salminen, T., Yan, Y.-L., Postlethwait, J.H., Johnson, M.S., Larhammar, D., and Scheinin, M. (2004) Identification of duplicated fourth {alpha}2-adrenergic receptor subtype by cloning and mapping of five receptor genes in zebrafish. Mol. Biol. Evol.. 10:14-28
Larson, E.T., Fredriksson, R., Johansson, S.R.T., and Larhammar, D. (2003) Cloning, pharmacology, and distribution of the neuropeptide Y-receptor Yb in rainbow trout. Peptides. 24(3):385-395
Dunér, T., Conlon, J.M., Kukkonen, J.P., Akerman, K.E.O., Yan, Y.-L., Postlethwait, J.H., and Larhammar, D. (2002) Cloning, structural characterization and functional expression of a zebrafish bradykinin B2-related receptor. Biochem. J.. 364(3):817-824
Ringholm, A., Fredriksson, R., Poliakova, N., Yan, Y.-L., Postlethwait, J.H., Larhammar, D., and Schiöth, H.B. (2002) One melanocortin 4 and two melanocortin 5 receptors from zebrafish show remarkable conservation in structure and pharmacology. J. Neurochem.. 82(1):6-18
Salaneck, E., Fredriksson, R., Larson, E.T., Conlon, J.M., and Larhammar, D. (2001) A neuropeptide Y receptor Y1-subfamily gene from an agnathan, the European river lamprey. Eur. J. Biochem.. 268(23):6146-6154
Berglund, M.M., Lundell, I., Cabrele, C., Serradeil-Le Gal, C., Beck-Sickinger, A.G., and Larhammar, D. (2000) Binding properties of three neuropeptide Y receptor subtypes from zebrafish: comparison with mammalian Y1 receptors. Biochem. Pharmacol.. 60(12):1815-1822
Söderberg, C., Wraith, A., Ringvall, M., Yan, Y.-L., Postlethwait, J.H., Brodin, L., and Larhammar, D. (2000) Zebrafish genes for neuropeptide Y and peptide YY reveal origin by chromosome duplication from an ancestral gene linked to the homeobox cluster. J. Neurochem.. 75(3):908-918
Sharma, P., Arvidsson, A.K., Wraith, A., Beck-Sickinger, A.G., Jönsson-Rylander, A.C., Larhammar, D. (1999) Characterization of the cloned Atlantic cod neuropeptide Y-Yb receptor: peptide-binding requirements distinct from known mammalian Y receptors. Gen. Comp. Endocrinol.. 115(3):422-428
Starbäck, P., Lundell, I., Fredriksson, R., Berglund, M.M., Yan, Y.-L., Wraith, A., Söderberg, C., Postlethwait, J.H., and Larhammar, D. (1999) Neuropeptide Y receptor subtype with unique properties cloned in the zebrafish: the zYa receptor. Mol. Brain Res.. 70(2):242-252
Arvidsson, A.K., Wraith, A., Jonsson-Rylander, A.C., and Larhammar, D. (1998) Cloning of a neuropeptide Y/peptide YY receptor from the Atlantic cod: the Yb receptor. Regul. Pept.. 76:39-43
Lundell, I., Ringvall, M., Starbäck, P., Salaneck, E., Berglund, M., and Larhammar, D. (1998) Cloning of neuropeptide Y receptors in zebrafish. Ann. N.Y. Acad. Sci.. 839:515-517
Postlethwait, J.H, Yan, Y.-L., Gates, M.A., Horne, S., Amores, A., Brownlie, A., Donovan, A., Egan, E.S., Force, A., Gong, Z., Goutel, C., Fritz, A., Kelsh, R., Knapik, E., Liao, E., Paw, B., Ransom, D., Singer, A., Thomson, M., Abduljabbar, T.S., Yelick, P., Beier, D., Joly, J.-S., Larhammar, D., Rosa, F., Westerfield, M., Zon, L.I., Johnson, S.L., and Talbot, W.S. (1998) Vertebrate genome evolution and the zebrafish gene map. Nature Genet.. 18:345-349
Risinger, C., Salaneck, E., Söderberg, C., Gates, M., Postlethwait, J.H., and Larhammar, D. (1998) Cloning of two loci for synapse protein Snap25 in zebrafish: comparison of paralogous linkage groups sugggests loss of one locus in the mammalian lineage. J. Neurosci. Res.. 54:563-573
Larhammar, D., Berglund, M.M., and Lundell, I. (1997) Multiplicity of NPY receptors - an evolutionary perspective. Reg. Pep.. 71:209
Lundell, I., Berglund, M.M., Starbäck, P., Salaneck, E., Gehlert, D.R., and Larhammar, D. (1997) Cloning and characterization of a novel neuropeptide Y receptor subtype in the zebrafish. DNA Cell Biol.. 16(11):1357-1363
Ringvall, M., Berglund, M.M., and Larhammar, D. (1997) Multiplicity of neruopeptide Y receptors: cloning of a third distinct subtype in the zebrafish. Biochem. Biophys. Res. Commun.. 241:749-755

Non-Zebrafish Publications:

Cerdá-Reverter, J. M., Martínez-Rodríguez, G., Zanuy, S., Carrillo, M., and Larhammar, D. Molecular evolution of the neuropeptide Y (NPY) family of peptides: cloning of NPY-related peptides from the sea bass (Dicentrarchus labrax). Regul. Peptides 95, 25-34 (2000).

The emphasis of the following article is on teleost peptides:

Cerdá-Reverter J. M. and Larhammar, D. Neuropeptide Y family of peptides: structure, anatomical expression, function, and molecular evolution. Biochem. Cell Biol. 78, 371-392 (2000).