Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-960805-312
Kuwada, John
Kuwada Lab
Department of Molecular, Cellular and Developmental Biology
The University of Michigan
830 North University Avenue
Ann Arbor, MI
48109-1048
USA
Phone: (734) 936-2842 Email: kuwada@umich.edu
FAX: (734) 647-0884 URL: http://www.mcdb.lsa.umich.edu/mcdb/people_detail/0,2098,723%255F20423,00.html
Biography and Research Interests:

Publications:
Hirata, H., Carta, E., Yamanaka, I., Harvey, R.J., and Kuwada, J.Y. (2010) Defective glycinergic synaptic transmission in zebrafish motility mutants. Front. Mol. Neurosci.. 2:26
Low, S.E., Ryan, J., Sprague, S.M., Hirata, H., Cui, W.W., Zhou, W., Hume, R.I., Kuwada, J.Y., and Saint-Amant, L. (2010) touche Is Required for Touch-Evoked Generator Potentials within Vertebrate Sensory Neurons. J. Neurosci.. 30(28):9359-9367
Low, S.E., Zhou, W., Choong, X., Saint-Amant, L., Sprague, S.M., Hirata, H., Cui, W.W., Hume, R.I., and Kuwada, J.Y. (2010) Na(V)1.6a is required for normal activation of motor circuits normally excited by tactile stimulation. Dev. Neurobiol.. 70(7):508-522
Dowling, J.J., Vreede, A.P., Low, S.E., Gibbs, E.M., Kuwada, J.Y., Bonnemann, C.G., and Feldman, E.L. (2009) Loss of myotubularin function results in T-tubule disorganization in zebrafish and human myotubular myopathy. PLoS Genet.. 5(2):e1000372
Low, S.E., Kuwada, J.Y., and Hume, R.I. (2008) Amino acid variations resulting in functional and nonfunctional zebrafish P2X(1) and P2X (5.1) receptors. Purinergic Signal.. 4(4):383-392
Saint-Amant, L., Sprague, S.M., Hirata, H., Li, Q., Cui, W.W., Zhou, W., Poudou, O., Hume, R.I., and Kuwada, J.Y. (2008) The zebrafish ennui behavioral mutation disrupts acetylcholine receptor localization and motor axon stability. Dev. Neurobiol.. 68(1):45-61
Zhou, W., Horstick, E.J., Hirata, H., and Kuwada, J.Y. (2008) Identification and expression of voltage-gated calcium channel beta subunits in Zebrafish. Dev. Dyn.. 237(12):3842-3852
Hirata, H., Watanabe, T., Hatakeyama, J., Sprague, S.M., Saint-Amant, L., Nagashima, A., Cui, W.W., Zhou, W., and Kuwada, J.Y. (2007) Zebrafish relatively relaxed mutants have a ryanodine receptor defect, show slow swimming and provide a model of multi-minicore disease. Development. 134(15):2771-2781
Sato-Maeda, M., Tawarayama, H., Obinata, M., Kuwada, J.Y., and Shoji, W. (2006) Sema3a1 guides spinal motor axons in a cell- and stage-specific manner in zebrafish. Development. 133(5):937-947
Sive, H., Mueller, T., Wullimann, M.F., Kuwada, J.Y., Moorman, S.J., Haendel, M.A. (2006) ZFIN Anatomy Working Group: Nervous System. Manually curated data.
Zhou, W., Saint-Amant, L., Hirata, H., Cui, W.W., Sprague, S.M., and Kuwada, J.Y. (2006) Non-sense mutations in the dihydropyridine receptor beta1 gene, CACNB1, paralyze zebrafish relaxed mutants. Cell Calcium. 39(3):227-236
Zhou, W., Shirabe, K., and Kuwada, J.Y. (2006) Molecular cloning and expression of two small leucine-rich proteoglycan (SLRP) genes, dspg3l and optcl, in zebrafish. Gene Expr. Patterns. 6(5):482-488
Cui, W.W., Low, S.E., Hirata, H., Saint-Amant, L., Geisler, R., Hume, R.I., and Kuwada, J.Y. (2005) The zebrafish shocked gene encodes a glycine transporter and is essential for the function of early neural circuits in the CNS. J. Neurosci.. 25(28):6610-6620
Haenisch, C., Diekmann, H., Klinger, M., Gennarini, G., Kuwada, J.Y., and Stuermer, C.A. (2005) The neuronal growth and regeneration associated Cntn1 (F3/F11/Contactin) gene is duplicated in fish: expression during development and retinal axon regeneration. Mol. Cell. Neurosci.. 28(2):361-374
Hirata, H., Saint-Amant, L., Downes, G.B., Cui, W.W., Zhou, W., Granato, M., and Kuwada, J.Y. (2005) Zebrafish bandoneon mutants display behavioral defects due to a mutation in the glycine receptor {beta}-subunit. Proc. Natl. Acad. Sci. USA. 102(23):8345-8350
Li, Q., Shirabe, K., Thisse, C., Thisse, B., Okamoto, H., Masai, I., and Kuwada, J.Y. (2005) Chemokine signaling guides axons within the retina in zebrafish. J. Neurosci.. 25(7):1711-1717
Cui, W.W., Saint-Amant, L., and Kuwada, J.Y. (2004) The shocked Gene is Required for the Function of a Premotor Network in the Zebrafish CNS. J. Neurophysiol.. 92(5):2898-2908
Hirata, H., Saint-Amant, L., Waterbury, J., Cui, W., Zhou, W., Li, Q., Goldman, D., Granato, M., and Kuwada, J.Y. (2004) accordion, a zebrafish behavioral mutant, has a muscle relaxation defect due to a mutation in the ATPase Ca2+ pump SERCA1. Development. 131(21):5457-5468
Li, Q., Shirabe, K., and Kuwada, J,Y. (2004) Chemokine signaling regulates sensory cell migration in zebrafish. Dev. Biol.. 269(1):123-136
Liu, Y., Berndt, J., Su, F., Tawarayama, H., Shoji, W., Kuwada, J.Y., and Halloran, M.C. (2004) Semaphorin3D guides retinal axons along the dorsoventral axis of the tectum. J. Neurosci.. 24(2):310-318
Song, M.H., Brown, N.L., and Kuwada, J.Y. (2004) The cfy mutation disrupts cell divisions in a stage-dependent manner in zebrafish embryos. Dev. Biol.. 276(1):194-206
Yeo, S.Y., Miyashita, T., Fricke, C., Little, M.H., Yamada, T., Kuwada, J.Y., Huh, T.L., Chien, C.B., and Okamoto, H. (2004) Involvement of Islet-2 in the Slit signaling for axonal branching and defasciculation of the sensory neurons in embryonic zebrafish. Mech. Dev.. 121(4):315-324
Geling, A., Itoh, M., Tallafuss, A., Chapouton, P., Tannhauser, B., Kuwada, J.Y., Chitnis, A.B., and Bally-Cuif, L. (2003) bHLH transcription factor Her5 links patterning to regional inhibition of neurogenesis at the midbrain-hindbrain boundary. Development. 130(8):1591-1604
Shoji, W., Isogai, S., Sato-Maeda, M., Obinata, M., and Kuwada, J.Y. (2003) Semaphorin3a1 regulates angioblast migration and vascular development in zebrafish embryos. Development. 130(14):3227-3236
Xiao, T., Shoji, W., Zhou, W., Su, F., and Kuwada, J.Y. (2003) Transmembrane Sema4E guides branchiomotor axons to their targets in zebrafish. J. Neurosci.. 23(10):4190-4198
Beattie, C.E., Granato, M., and Kuwada, J.Y. (2002) Cellular, genetic and molecular mechanisms of axonal guidance in the zebrafish. Results Probl. Cell Diff.. 40:252-269
Blechinger, S.R., Evans, T.G., Tang, P.T., Kuwada, J.Y., Warren, J.T., and Krone, P.H. (2002) The heat-inducible zebrafish hsp70 gene is expressed during normal lens development under non-stress conditions. Mech. Dev.. 112(1-2):213-215
Blechinger, S.R., Warren, J.T., Kuwada, J.Y., and Krone, P.H. (2002) Developmental toxicology of cadmium in living embryos of a stable transgenic zebrafish line. Environ. Health Perspect.. 119(19):1041-1046
Masumoto, J., Zhou, W., Chen, F.F., Su, F., Kuwada, J.Y., Hidaka, E., Katsuyama, T., Sagara, J., Taniguchi, S., Ngo-Hazelett, P., Postlethwait, J.H., Nuņez, G., and Inohara, N. (2002) Caspy: A Zebrafish caspase activated by ASC oligomerization required for pharyngeal Arch development. J. Biol. Chem.. 278(6):4268-4276
Scheer, N., Riedl, I., Warren, J.T., Kuwada, J.Y., and Campos-Ortega, J.A. (2002) A quantitative analysis of the kinetics of Gal4 activator and effector gene expression in the zebrafish. Mech. Dev.. 112(1-2):9-14
Yeo, S.Y., Little, M.H., Yamada, T., Miyashita, T., Halloran, M.C., Kuwada, J.Y., Huh, T.L., and Okamoto, H. (2001) Overexpression of a slit homologue impairs convergent extension of the mesoderm and causes cyclopia in embryonic zebrafish. Dev. Biol.. 230(1):1-17
Halloran, M.C., Sato-Maeda, M., Warren, J.T., Su, F., Lele, Z., Krone, P.H., Kuwada, J.Y., and Shoji, W. (2000) Laser-induced gene expression in specific cells of transgenic zebrafish. Development. 127(9):1953-1960
Kanki, J.P. and Kuwada, J.Y. (2000) Growth cones utilize both widespread and local directional cues in the zebrafish brain. Dev. Biol.. 219(2):364-372
Chandrasekhar, A., Schauerte, H.E., Haffter, P., and Kuwada, J.Y. (1999) The zebrafish detour gene is essential for cranial but not spinal motor neuron induction. Development. 126(12):2727-2737
Halloran, M.C., Severance, S.M., Yee, C.S., Gemza, D.L., Raper, J.A., and Kuwada, J.Y. (1999) Analysis of zebrafish semaphorin reveals potential functions in vivo. Dev. Dyn.. 214:13-25
Warren, J.T., Jr., Chandrasekhar, A., Kanki, J.P., Rangarajan, R., Furley, A.J., and Kuwada, J.Y. (1999) Molecular cloning and developmental expression of a zebrafish axonal glycoprotein similar to TAG-1. Mech. Dev.. 80(2):197-201
Yee, C.S., Chandrasekhar, A., Halloran, M.C., Shoji, W., Warren, J.T., and Kuwada, J.Y. (1999) Molecular cloning, expression, and activity of zebrafish semaphorin Z1a. Brain Res. Bull.. 48(6):581-593
Chandrasekhar, A., Warren, Jr., J.T., Takahashi, K., Schauerte, H.E., van Eeden, F.J.M., Haffter, Pl, and Kuwada, J.Y. (1998) Role of sonic hedgehog in branchiomotor neuron induction in zebrafish. Mech. Dev.. 76:101-115
Halloran, M.C., Severance, S.M., Yee, C.S., Gemza, D.L., and Kuwada, J.Y. (1998) Molecular cloning and expression of two novel zebrafish semaphorins. Mech. Dev.. 76:165-168
Lauderdale, J.D., Pasquali, S.K., Fazel, R., van Eeden, F.J., Schauerte, H.E., Haffter, P., and Kuwada, J.Y. (1998) Regulation of netrin-1a expression by hedgehog proteins. Mol. Cell Neurosci.. 11:194-205
Shoji, W., Yee, C.S., and Kuwada, J.Y. (1998) Zebrafish semaphorin Z1a collapses specific growth cones and alters their pathway in vivo. Development. 125:1275-1283
Chandrasekhar, A., Moens, C.B., Warren, J.T., Kimmel, C.B., and Kuwada, J.Y. (1997) Development of branchiomotor neurons in zebrafish. Development. 124(13):2633-2644
Kuwada, J.Y. (1997) Role of semaphorins in growth cone guidance in the zebrafish embryo. Neurosci. Res.. 7-29
Lauderdale, J.D., Davis, N.M., and Kuwada, J.Y. (1997) Axon tracts correlate with Netrin-1a expression in the zebrafish embryo. Mol. Cell Neurosci.. 9(4):293-313
Greenspoon, S., Patel, C.K., Hashmi, S., Bernhardt, R.R., and Kuwada, J.Y. (1995) The notochord and floor plate guide growth cones in the zebrafish spinal cord. J. Neurosci.. 15:5956-5965
Kuwada, J.Y. (1995) Development of the zebrafish nervous system: genetic analysis and manipulation. Curr. Opin. Neurobiol.. 5:50-54
Kanki, J.P., Chang, S., and Kuwada, J.Y. (1994) The molecular cloning and characterization of potential chick DM-GRASP homologs in zebrafish and mouse. J. Neurobiol.. 25:831-845
Patel, C.K., Rodriguez, L.C., and Kuwada, J. (1994) Axonal outgrowth within the abnormal scaffold of brain tracts in a zebrafish mutant. J. Neurobiol.. 25:345-360
Kuwada, J.Y. (1993) Pathway selection by growth cones in the zebrafish central nervous system. Perspect. Dev. Neurobiol.. 1:195-203
Bernhardt, R.R., Nguyen, N., and Kuwada, J.Y. (1992) Growth cone guidance by floor plate cells in the spinal cord of zebrafish embryos. Neuron. 8:869-882
Bernhardt, R.R., Patel, C.K., Wilson, S.W., and Kuwada, J.Y. (1992) Axonal trajectories and distribution of GABAergic spinal neurons in wildtype and mutant zebrafish lacking floor plate cells. J. Comp. Neurol.. 326:263-272
Chitnis, A.B., Patel, C.K., Kim, S., and Kuwada, J.Y. (1992) A specific brain tract guides follower growth cones in two regions of the zebrafish brain. J. Neurobiol.. 23:845-854
Kuwada, J.Y. (1992) Growth cone guidance in the zebrafish central nervous system. Curr. Opin. Neurobiol.. 2:31-35
Mikkola, I., Fjose, A., Kuwada, J.Y., Wilson, S., Guddal, P.H., and Krauss, S. (1992) The paired domain-containing nuclear factor pax[b] is expressed in specific commissural interneurons in zebrafish embryos. J. Neurobiol.. 23:933-946
Chitnis, A.B. and Kuwada, J.Y. (1991) Elimination of a brain tract increases errors in pathfinding by follower growth cones in the zebrafish embryo. Neuron. 7:277-285
Chitnis, A.B., Patel, C.K., and Kuwada, J.Y. (1991) A specific brain tract guides follower growth cones in two regions of the zebrafish brain. Soc. Neurosci. Abstr.. 17:40
Bernhardt, R.R., Chitnis, A.B., Lindamer, L., and Kuwada, J.Y. (1990) Identification of spinal neurons in the embryonic and larval zebrafish. J. Comp. Neurol.. 302:603-616
Chitnis, A.B. and Kuwada, J.Y. (1990) Axonogenesis in the brain of zebrafish embryos. J. Neurosci.. 10:1892-1905
Kuwada, J.Y. and Bernhardt, R.R. (1990) Axonal outgrowth by identified neurons in the spinal cord of zebrafish embryos. Exp. Neurol.. 109:29-34
Kuwada, J.Y. and Hatta, K. (1990) Axonal pathfinding in the cord of zebrafish mutants missing the floor plate FP. Soc. Neurosci. Abstr.. 16:309
Kuwada, J.Y., Bernhardt, R.R., and Chitnis, A.B. (1990) Pathfinding by identified growth cones in the spinal cord of zebrafish embryos. J. Neurosci.. 10:1299-1308
Kuwada, J.Y., Bernhardt, R.R., and Nguyen, N. (1990) Development of spinal neurons and tracts in the zebrafish embryo. J. Comp. Neurol.. 302:617-628
Kuwada, J.Y., Bernhardt, R.R., Chitnis, A.B., and Nguyen, N. (1989) Pathfinding by spinal growth cones in the zebrafish embryo. Soc. Neurosci. Abstr.. 15:1028
Kuwada, J.Y., Chitnis, A., and Lindamer, L.A. (1987) Stereotyped pathfinding by identified growth cones in the embryonic spinal cord. Soc. Neurosci. Abstr.. 13:1220
Kuwada, J.Y. (1986) Cell recognition by neuronal growth cones in a simple vertebrate embryo. Science.. 233:740-746

Non-Zebrafish Publications: