Gene

d2hgdh

ID

ZDB-GENE-070112-482

Name

D-2-hydroxyglutarate dehydrogenase

Symbol

d2hgdh Nomenclature History

Previous Names

zgc:158661

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Predicted to have FAD binding activity and oxidoreductase activity. Predicted to be involved in oxidation-reduction process. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in D-2-hydroxyglutaric aciduria 1. Orthologous to human D2HGDH (D-2-hydroxyglutarate dehydrogenase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With d2hgdh Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
D-2-hydroxyglutaric aciduria 1	Alliance	D-2-hydroxyglutaric aciduria	600721

Associated With d2hgdh Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR004113	FAD-binding oxidoreductase/transferase, type 4, C-terminal
Domain	IPR006094	FAD linked oxidase, N-terminal
Domain	IPR016166	FAD-binding domain, PCMH-type
Homologous_superfamily	IPR016164	FAD-linked oxidase-like, C-terminal
Homologous_superfamily	IPR016167	FAD-binding, type PCMH, subdomain 1
Homologous_superfamily	IPR016169	FAD-binding, type PCMH, subdomain 2
Homologous_superfamily	IPR016171	Vanillyl-alcohol oxidase, C-terminal subdomain 2
Homologous_superfamily	IPR036318	FAD-binding, type PCMH-like superfamily