Gene

col18a1a

ID

ZDB-GENE-030516-3

Name

collagen type XVIII alpha 1 chain a

Symbol

col18a1a Nomenclature History

Previous Names

cb371 (1)
col18a1
cb529 (1)
fc96d06
sb:cb529 (1)
wu:fb47h10
wu:fb77g12
wu:fc50f04
wu:fc96d06
wu:fk02h12

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to have extracellular matrix structural constituent. Involved in neural crest cell migration. Predicted to localize to extracellular matrix and extracellular space. Is expressed in several structures, including anterior neural keel; digestive system; nervous system; neural plate; and pronephros. Orthologous to human COL18A1 (collagen type XVIII alpha 1 chain).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

25 figures from 8 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

cb529 (20 images)
cb371 (21 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Banerjee et al., 2013
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With col18a1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Glaucoma, primary closed-angle	618880
		Knobloch syndrome, type 1	267750

Associated With col18a1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR010515	Collagenase NC10/endostatin
Domain	IPR020067	Frizzled domain
Domain	IPR035523	Collagen alpha-1(XVIII) chain, frizzled domain
Domain	IPR045463	Collagen type XV/XVIII, trimerization domain
Domain	IPR048287	Thrombospondin-like, N-terminal domain
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily	IPR016186	C-type lectin-like/link domain superfamily
Homologous_superfamily	IPR016187	C-type lectin fold
Homologous_superfamily	IPR036790	Frizzled cysteine-rich domain superfamily
Repeat	IPR008160	Collagen triple helix repeat

Domain Details Per Protein

Protein	Length	Collagen alpha-1(XVIII) chain, frizzled domain	Collagenase NC10/endostatin	Collagen triple helix repeat	Collagen type XV/XVIII, trimerization domain	Concanavalin A-like lectin/glucanase domain superfamily	C-type lectin fold	C-type lectin-like/link domain superfamily	Frizzled cysteine-rich domain superfamily	Frizzled domain	Thrombospondin-like, N-terminal domain
UniProtKB:A0A8M9QFI3 InterPro	1437
UniProtKB:B0S8G5 InterPro	1383
UniProtKB:A0A8M9PS88 InterPro	1349
UniProtKB:A0A8M9QJR2 InterPro	1645

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	col18a1a-201 (1) Ensembl	Havana	5579 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	col18a1a-202 (1) Ensembl	Havana	5515 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	col18a1a-203 (1) Ensembl	Havana	6365 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations