Gene

kmt2e

ID

ZDB-GENE-030131-4120

Name

lysine (K)-specific methyltransferase 2E

Symbol

kmt2e Nomenclature History

Previous Names

mll5
wu:fc74b02
zgc:64223

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to have metal ion binding activity. Human ortholog(s) of this gene implicated in autistic disorder and cervical cancer. Is expressed in central nervous system and intermediate cell mass of mesoderm. Orthologous to human KMT2E (lysine methyltransferase 2E).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:64223 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from Thyme et al., 2019
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With kmt2e Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		O'Donnell-Luria-Rodan syndrome	618512

Associated With kmt2e Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019786	Zinc finger, PHD-type, conserved site
Domain	IPR001214	SET domain
Domain	IPR001965	Zinc finger, PHD-type
Domain	IPR019787	Zinc finger, PHD-finger
Domain	IPR044434	KMT2E, SET domain
Homologous_superfamily	IPR011011	Zinc finger, FYVE/PHD-type
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily	IPR046341	SET domain superfamily

Domain Details Per Protein

Protein	Length	KMT2E, SET domain	SET domain	SET domain superfamily	Zinc finger, FYVE/PHD-type	Zinc finger, PHD-finger	Zinc finger, PHD-type	Zinc finger, PHD-type, conserved site	Zinc finger, RING/FYVE/PHD-type
UniProtKB:A0A8M2BC51 InterPro	1598
UniProtKB:A0A8N7UVB9 InterPro	1631
UniProtKB:A0A8M9Q6C7 InterPro	1655
UniProtKB:A0A8M2BC59 InterPro	1622

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	kmt2e-201 (1) Ensembl	Havana	2704 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	kmt2e-202 (1) Ensembl	Havana	4168 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations