Gene

nags

ID
ZDB-GENE-121219-2
Name
N-acetylglutamate synthase
Symbol
nags Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Exhibits acetyl-CoA:L-glutamate N-acetyltransferase activity and arginine binding activity. Predicted to be involved in arginine biosynthetic process. Predicted to localize to mitochondrial matrix. Human ortholog(s) of this gene implicated in amino acid metabolic disorder. Orthologous to human NAGS (N-acetylglutamate synthase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Caldovic et al., 2014
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nags Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
N-acetylglutamate synthase deficiency Alliance N-acetylglutamate synthase deficiency 237310
Associated With nags Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR006855 Vertebrate-like NAGS Gcn5-related N-acetyltransferase (GNAT) domain
Family IPR011243 N-acetylglutamate synthase, animal
Homologous_superfamily IPR016181 Acyl-CoA N-acyltransferase
Homologous_superfamily IPR036393 Acetylglutamate kinase-like superfamily
Domain Details Per Protein
Protein Length Acetylglutamate kinase-like superfamily Acyl-CoA N-acyltransferase N-acetylglutamate synthase, animal Vertebrate-like NAGS Gcn5-related N-acetyltransferase (GNAT) domain
UniProtKB:E7FCP8 527
UniProtKB:A0A8M9PWK2 526
UniProtKB:A0A8M9PJE2 526
UniProtKB:A0A8M9P8E6 527
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations