Gene

zgc:158659

ID
ZDB-GENE-070112-492
Name
zgc:158659
Symbol
zgc:158659 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to have 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Predicted to be involved in cell migration; phosphatidylinositol 3-kinase signaling; and phosphatidylinositol metabolic process. Predicted to localize to cytoplasm; phosphatidylinositol 3-kinase complex, class IA; and plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including CLOVES syndrome; Cowden syndrome; breast cancer (multiple); colorectal cancer (multiple); and cutaneous Paget's disease. Orthologous to human PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With zgc:158659 Human Ortholog
No data available
Associated With zgc:158659 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
Domain IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
Domain IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
Domain IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
Domain IPR002420 C2 phosphatidylinositol 3-kinase-type domain
Domain IPR003113 Phosphatidylinositol 3-kinase, adaptor-binding domain
Family IPR015433 Phosphatidylinositol kinase
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR016024 Armadillo-type fold
Homologous_superfamily IPR029071 Ubiquitin-like domain superfamily
Homologous_superfamily IPR035892 C2 domain superfamily
Homologous_superfamily IPR036940 Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
Homologous_superfamily IPR042236 Phosphoinositide 3-kinase, accessory (PIK) domain superfamily
Domain Details Per Protein
Protein Length Armadillo-type fold C2 domain superfamily C2 phosphatidylinositol 3-kinase-type domain Phosphatidylinositol 3-/4-kinase, catalytic domain Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily Phosphatidylinositol 3/4-kinase, conserved site Phosphatidylinositol 3-kinase, adaptor-binding domain Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain Phosphatidylinositol kinase Phosphoinositide 3-kinase, accessory (PIK) domain Phosphoinositide 3-kinase, accessory (PIK) domain superfamily Protein kinase-like domain superfamily Ubiquitin-like domain superfamily
UniProtKB:A1L256 287
UniProtKB:A0A8M2BHX1 1070
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations