Gene

isca1

ID
ZDB-GENE-050626-94
Name
iron-sulfur cluster assembly 1
Symbol
isca1 Nomenclature History
Previous Names
  • magr (1)
  • zgc:114185
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have 2 iron, 2 sulfur cluster binding activity. Involved in heme biosynthetic process. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 5. Is expressed in several structures, including eye; heart; integument; liver; and pleuroperitoneal region. Orthologous to human ISCA1 (iron-sulfur cluster assembly 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Nilsson et al., 2009
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With isca1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
multiple mitochondrial dysfunctions syndrome 5 Alliance Multiple mitochondrial dysfunctions syndrome 5 617613
Associated With isca1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017870 FeS cluster insertion, C-terminal, conserved site
Domain IPR000361 FeS cluster biogenesis
Family IPR016092 FeS cluster insertion protein
Homologous_superfamily IPR035903 HesB-like domain superfamily
Domain Details Per Protein
Protein Length FeS cluster biogenesis FeS cluster insertion, C-terminal, conserved site FeS cluster insertion protein HesB-like domain superfamily
UniProtKB:Q4QRC6 129
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations