Gene

arl6

ID

ZDB-GENE-041219-2

Name

ADP-ribosylation factor-like 6

Symbol

arl6 Nomenclature History

Previous Names

bbs3 (1)
zgc:101762

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have GTP binding activity. Involved in several processes, including Kupffer's vesicle development; melanosome transport; and regulation of Notch signaling pathway. Predicted to localize to axoneme. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 1; Bardet-Biedl syndrome 3; and retinitis pigmentosa 55. Is expressed in adipose tissue; brain; eye; heart; and retina. Orthologous to human ARL6 (ADP ribosylation factor like GTPase 6).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:101762 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With arl6 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Bardet-Biedl syndrome 1	Alliance	{Bardet-Biedl syndrome 1, modifier of}	209900
Bardet-Biedl syndrome 3	Alliance	Bardet-Biedl syndrome 3	600151
retinitis pigmentosa 55	Alliance	Retinitis pigmentosa 55	613575

Associated With arl6 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005225	Small GTP-binding protein domain
Family	IPR006689	Small GTPase superfamily, ARF/SAR type
Family	IPR024156	Small GTPase superfamily, ARF type
Family	IPR041839	ADP-ribosylation factor-like protein 6
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase