Gene

rpl11

ID

ZDB-GENE-040625-147

Name

ribosomal protein L11

Symbol

rpl11 Nomenclature History

Previous Names

zgc:86748

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to have RNA binding activity. Involved in several processes, including erythrocyte development; glucose homeostasis; and hemoglobin biosynthetic process. Predicted to localize to cytosolic large ribosomal subunit. Used to study Diamond-Blackfan anemia. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia and T-cell acute lymphoblastic leukemia. Is expressed in endodermal cell; eye; intestine; liver; and pancreas. Orthologous to human RPL11 (ribosomal protein L11).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 5 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 37 figures from 16 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rpl11 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Diamond-Blackfan anemia 7	Alliance	Diamond-Blackfan anemia 7	612562

Associated With rpl11 Via Experimental Models

Human Disease	Fish	Conditions	Citations
Diamond-Blackfan anemia	WT + MO1-rpl11	standard conditions	(3)
Diamond-Blackfan anemia	rpl11^{hi3820bTg/hi3820bTg}	standard conditions	(2)
Diamond-Blackfan anemia	rpl11^{hi3820bTg/hi3820bTg}	standard conditions	(3)

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR020929	Large ribosomal subunit protein uL5, conserved site
Domain	IPR031309	Large ribosomal subunit protein uL5, C-terminal
Domain	IPR031310	Large ribosomal subunit protein uL5, N-terminal
Family	IPR002132	Large ribosomal subunit protein uL5
Homologous_superfamily	IPR022803	Large ribosomal subunit protein uL5 domain superfamily

Domain Details Per Protein

Protein	Length	Large ribosomal subunit protein uL5	Large ribosomal subunit protein uL5, conserved site	Large ribosomal subunit protein uL5, C-terminal	Large ribosomal subunit protein uL5 domain superfamily	Large ribosomal subunit protein uL5, N-terminal
UniProtKB:Q6IQI6 InterPro PDB	178

Transcripts

Genome Browsers

NCBI

No data available

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-rpl11	polyclonal	rpl11		Rabbit	WB	Abcam plc	4

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations