Gene

tlr1

ID

ZDB-GENE-040220-1

Name

toll-like receptor 1

Symbol

tlr1 Nomenclature History

Previous Names

tlr6 (1)
TIR1.2 (1)

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to have signaling receptor activity. Predicted to be involved in inflammatory response and toll-like receptor signaling pathway. Predicted to localize to integral component of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; aspergillosis; asthma; leprosy; and pyelonephritis. Orthologous to human TLR1 (toll like receptor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

7 figures from 5 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tlr1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Leprosy, protection against}	613223
		{Leprosy, susceptibility to, 5}	613223

Associated With tlr1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000157	Toll/interleukin-1 receptor homology (TIR) domain
Domain	IPR000483	Cysteine-rich flanking region, C-terminal
Family	IPR017241	Toll-like receptor
Homologous_superfamily	IPR032675	Leucine-rich repeat domain superfamily
Homologous_superfamily	IPR035897	Toll/interleukin-1 receptor homology (TIR) domain superfamily
Repeat	IPR001611	Leucine-rich repeat
Repeat	IPR003591	Leucine-rich repeat, typical subtype