Gene

mat1a

ID
ZDB-GENE-030131-6127
Name
methionine adenosyltransferase 1A
Symbol
mat1a Nomenclature History
Previous Names
  • wu:fi35e01
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to have methionine adenosyltransferase activity. Predicted to be involved in S-adenosylmethionine biosynthetic process and one-carbon metabolic process. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in hypermethioninemia. Is expressed in several structures, including anterior neural tube; lens; liver; optic cup; and yolk syncytial layer. Orthologous to human MAT1A (methionine adenosyltransferase 1A).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mat1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Hypermethioninemia, persistent, autosomal dominant, due to methionine adenosyltransferase I/III deficiency 250850
Methionine adenosyltransferase deficiency, autosomal recessive 250850
Associated With mat1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR022631 S-adenosylmethionine synthetase, conserved site
Domain IPR022628 S-adenosylmethionine synthetase, N-terminal
Domain IPR022629 S-adenosylmethionine synthetase, central domain
Domain IPR022630 S-adenosylmethionine synthetase, C-terminal
Family IPR002133 S-adenosylmethionine synthetase
Homologous_superfamily IPR022636 S-adenosylmethionine synthetase superfamily
Domain Details Per Protein
Protein Length S-adenosylmethionine synthetase S-adenosylmethionine synthetase, central domain S-adenosylmethionine synthetase, conserved site S-adenosylmethionine synthetase, C-terminal S-adenosylmethionine synthetase, N-terminal S-adenosylmethionine synthetase superfamily
UniProtKB:Q7ZW04 390
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations