Gene
vps18
- ID
- ZDB-GENE-020419-33
- Name
- VPS18 core subunit of CORVET and HOPS complexes
- Symbol
- vps18 Nomenclature History
- Previous Names
-
- chunp6929
- hm:zehl0587
- wu:fj35h10 (1)
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have protein binding activity, bridging. Involved in several processes, including apical protein localization; endosome to pigment granule transport; and notochord cell vacuolation. Predicted to localize to HOPS complex and endosome. Used to study cholestasis. Orthologous to human VPS18 (VPS18 core subunit of CORVET and HOPS complexes).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103535 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| cholestasis | vps18hi2499aTg | standard conditions | Sadler et al., 2005 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Clathrin, heavy chain/VPS, 7-fold repeat | Pep3/Vps18/deep orange, beta-propeller domain |
|---|---|---|---|
|
UniProtKB:P59015
|
974 | ||
|
UniProtKB:B7ZVV5
|
974 |
Interactions and Pathways
No data available
Plasmids
No data available