Research
General Information
ZIRC
ZFIN ID: ZDB-LAB-990120-1
Baier Lab
Department of Physiology
University of California, San Francisco
Mission Bay, Rock Hall
1550 4th Street
San Francisco, CA 94158-2324
USA
Contact Info:
Contact Person: Baier, Herwig
Phone: (415) 502-4301
Fax: (415) 514-4360
Email: herwig.baier@ucsf.edu
URL: http://baierlab.ucsf.edu/
Line Designation: s 		Lab Members:
Baier, Herwig , PI/Director
Charles, Anne-Sophie de Preux , Post-Doc
Del Bene, Filippo , Post-Doc
Lucido, Anna Lisa , Post-Doc
Nevin, Linda , Post-Doc
Robles, Estuardo , Post-Doc
Schoonheim, Peter , Post-Doc
Semmelhack, Julie , Post-Doc
Thiele, Tod , Post-Doc
Arrenberg, Ari , Graduate Student
Donovan, Joseph , Graduate Student
Finger-Baier, Karin , Research Staff
Staub, Wendy , Research Staff
Xiao, Tong , Research Staff
Statement of Research Interests:

We are interested in the relationship between genes, neural circuits, and behavior.

Keywords:
• Visual system
• Retina and tectum
• Hypothalamus
• Spinal and reticulospinal circuits
• Neuronal cell-type diversity
• Synaptic specificity
• Optomotor and optokinetic behavior
• Psychophysics
• Segregation of visual pathways
• Synaptic homeostasis
• Light adaptation
• Models of neuro-psychiatric disorders
• Screening, mapping, and cloning of mutations
• Bioinformatics; conserved non-coding elements
• GAL4/UAS enhancer trapping
• Optical imaging; optophysiology with genetically encoded indicators
• Optogenetic and chemical-genetic manipulations of neuronal function
• Channelrhodopsin; halorhodopsin; LiGluR; GluCl

Zebrafish Publications of Lab members :
Arrenberg, A.B., Del Bene, F., and Baier, H. (2009) Optical control of zebrafish behavior with halorhodopsin. Proc. Natl. Acad. Sci. USA. 106(42):17968-17973
Baier, H., and Scott, E.K. (2009) Genetic and optical targeting of neural circuits and behavior-zebrafish in the spotlight. Curr. Opin. Neurobiol.. 19(5):553-560
Gosse, N.J., and Baier, H. (2009) An essential role for Radar (Gdf6a) in inducing dorsal fate in the zebrafish retina. Proc. Natl. Acad. Sci. USA. 106(7):2236-2241
Kurrasch, D.M., Nevin, L.M., Wong, J., Baier, H., and Ingraham, H.A. (2009) Neuroendocrine transcriptional programs adapt dynamically to the supply and demand for neuropeptides as revealed in NSF mutant zebrafish. Neural Develop.. 4:22
Maddison, L.A., Lu, J., Victoroff, T., Scott, E., Baier, H., and Chen, W. (2009) A gain-of-function screen in zebrafish identifies a guanylate cyclase with a role in neuronal degeneration. Mol. Genet. Genomics. 281(5):551-563
Mason, L., Scott, E.K., Staub, W., Finger-Baier, K., and Baier, H. (2009) Expression patterns from GAL4 enhancer trap screen. ZFIN Direct Data Submission.
Scott, E.K., and Baier, H. (2009) The cellular architecture of the larval zebrafish tectum, as revealed by gal4 enhancer trap lines. Front. Neural Circuits. 3:13
Seipold, S., Priller, F.C., Goldsmith, P., Harris, W.A., Baier, H., and Abdelilah-Seyfried, S. (2009) Non-SMC condensin I complex proteins control chromosome segregation and survival of proliferating cells in the zebrafish neural retina. BMC Dev. Biol.. 9:40
Wyart, C., Bene, F.D., Warp, E., Scott, E.K., Trauner, D., Baier, H., and Isacoff, E.Y. (2009) Optogenetic dissection of a behavioural module in the vertebrate spinal cord. Nature. 461(7262):407-410
Chi, N.C., Shaw, R.M., Jungblut, B., Huisken, J., Ferrer, T., Arnaout, R., Scott, I., Beis, D., Xiao, T., Baier, H., Jan, L.Y., Tristani-Firouzi, M., and Stainier, D.Y. (2008) Genetic and Physiologic Dissection of the Vertebrate Cardiac Conduction System. PLoS Biol.. 6(5):e109
Del Bene, F., Wehman, A.M., Link, B.A., and Baier, H. (2008) Regulation of neurogenesis by interkinetic nuclear migration through an apical-basal notch gradient. Cell. 134(6):1055-1065
Gosse, N.J., Nevin, L.M., and Baier, H. (2008) Retinotopic order in the absence of axon competition. Nature. 452(7189):892-895
Nevin, L. (2008) Cellular and molecular mechanisms of neurite targeting in the zebrafish visual system. Ph.D. Thesis, University of California, San Francisco. 130p
Nevin, L.M., Taylor, M.R., and Baier, H. (2008) Hardwiring of fine synaptic layers in the zebrafish visual pathway. Neural Develop.. 3:36
Sumbre, G., Muto, A., Baier, H., and Poo, M.M. (2008) Entrained rhythmic activities of neuronal ensembles as perceptual memory of time interval. Nature. 456(7218):102-106
Campbell, D.S., Stringham, S.A., Timm, A., Xiao, T., Law, M.Y., Baier, H., Nonet, M.L., and Chien, C.B. (2007) Slit1a inhibits retinal ganglion cell arborization and synaptogenesis via Robo2-dependent and -independent pathways. Neuron. 55(2):231-245
Davison, J.M., Akitake, C.M., Goll, M.G., Rhee, J.M., Gosse, N., Baier, H., Halpern, M.E., Leach, S.D., and Parsons, M.J. (2007) Transactivation from Gal4-VP16 transgenic insertions for tissue-specific cell labeling and ablation in zebrafish. Dev. Biol.. 304(2):811-824
Jin, S.W., Herzog, W., Santoro, M.M., Mitchell, T.S., Frantsve, J., Jungblut, B., Beis, D., Scott, I.C., D'Amico, L.A., Ober, E.A., Verkade, H., Field, H.A., Chi, N.C., Wehman, A.M., Baier, H., and Stainier, D.Y. (2007) A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos. Dev. Biol.. 307(1):29-42
Scott, E.K., Mason, L., Arrenberg, A.B., Ziv, L., Gosse, N.J., Xiao, T., Chi, N.C., Asakawa, K., Kawakami, K., and Baier, H. (2007) Targeting neural circuitry in zebrafish using GAL4 enhancer trapping. Nat. Methods. 4(4):323-326
Scott, I.C., Masri, B., D'Amico, L.A., Jin, S.W., Jungblut, B., Wehman, A.M., Baier, H., Audigier, Y., and Stainier, D.Y. (2007) The G protein-coupled receptor agtrl1b regulates early development of myocardial progenitors. Dev. Cell. 12(3):403-413
Smear, M.C., Tao, H.W., Staub, W., Orger, M.B., Gosse, N.J., Liu, Y., Takahashi, K., Poo, M.M., and Baier, H. (2007) Vesicular Glutamate Transport at a Central Synapse Limits the Acuity of Visual Perception in Zebrafish. Neuron. 53(1):65-77
Szobota, S., Gorostiza, P., Del Bene, F., Wyart, C., Fortin, D.L., Kolstad, K.D., Tulyathan, O., Volgraf, M., Numano, R., Aaron, H.L., Scott, E.K., Kramer, R.H., Flannery, J., Baier, H., Trauner, D., and Isacoff, E.Y. (2007) Remote control of neuronal activity with a light-gated glutamate receptor. Neuron. 54(4):535-545
Wehman, A.M., Staub, W., and Baier, H. (2007) The anaphase-promoting complex is required in both dividing and quiescent cells during zebrafish development. Dev. Biol.. 303(1):144-156
Xiao, T., and Baier, H. (2007) Lamina-specific axonal projections in the zebrafish tectum require the type IV collagen Dragnet. Nat. Neurosci.. 10(12):1529-1537
Mumm, J.S., Williams, P.R., Godinho, L., Koerber, A., Pittman, A.J., Roeser, T., Chien, C.B., Baier, H., and Wong, R.O. (2006) In vivo imaging reveals dendritic targeting of laminated afferents by zebrafish retinal ganglion cells. Neuron. 52(4):609-621
Baraban, S.C., Taylor, M.R., Castro, P.A., and Baier, H. (2005) Pentylenetetrazole induced changes in zebrafish behavior, neural activity and c-fos expression. Neuroscience. 131(3):759-768
Beis, D., Bartman, T., Jin, S.W., Scott, I.C., D'Amico, L.A., Ober, E.A., Verkade, H., Frantsve, J., Field, H.A., Wehman, A., Baier, H., Tallafuss, A., Bally-Cuif, L., Chen, J.N., Stainier, D.Y., and Jungblut, B. (2005) Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development. Development. 132(18):4193-4204
Gahtan. E., Tanger. P., and Baier, H. (2005) Visual prey capture in larval zebrafish is controlled by identified reticulospinal neurons downstream of the tectum. J. Neurosci.. 25(40):9294-9303
Hua, J.Y., Smear, M.C., Baier, H., and Smith, S.J. (2005) Regulation of axon growth in vivo by activity-based competition. Nature. 434(7036):1022-1026
Kay, J.N., Link, B.A., and Baier, H. (2005) Staggered cell-intrinsic timing of ath5 expression underlies the wave of ganglion cell neurogenesis in the zebrafish retina. Development. 132(11):2573-2585
Martinez-Morales, J.R., Del Bene, F., Nica, G., Hammerschmidt, M., Bovolenta, P., and Wittbrodt, J. (2005) Differentiation of the vertebrate retina is coordinated by an FGF signaling center. Dev. Cell. 8(4):565-574
Muto, A., Orger, M.B., Wehman, A.M., Smear, M.C., Kay, J.N., Page-McCaw, P.S., Gahtan, E., Xiao, T., Nevin, L.M., Gosse, N.J., Staub, W., Finger-Baier, K., Baier, H. (2005) Forward Genetic Analysis of Visual Behavior in Zebrafish. PLoS Genet.. 1(5):e66
Orger, M.B., and Baier, H. (2005) Channeling of red and green cone inputs to the zebrafish optomotor response. Vis. Neurosci.. 22(3):275-281
Seiler, C., Finger-Baier, K.C., Rinner, O., Makhankov, Y.V., Schwarz, H., Neuhauss, S.C., and Nicolson, T. (2005) Duplicated genes with split functions: independent roles of protocadherin15 orthologues in zebrafish hearing and vision. Development. 132(3):615-623
Wehman, A.M., Staub, W., Meyers, J.R., Raymond, P.A., and Baier, H. (2005) Genetic dissection of the zebrafish retinal stem-cell compartment. Dev. Biol.. 281(1):53-65
Xiao, T., Roeser, T., Staub, W., and Baier, H. (2005) A GFP-based genetic screen reveals mutations that disrupt the architecture of the zebrafish retinotectal projection. Development. 132(13):2955-2967
Gahtan, E., and Baier, H. (2004) Of lasers, mutants, and see-through brains: Functional neuroanatomy in zebrafish. J. Neurobiol.. 59(1):147-161
Kay, J.N., Roeser, T., Mumm, J.S., Godinho, L., Mrejeru, A., Wong, R.O., and Baier, H. (2004) Transient requirement for ganglion cells during assembly of retinal synaptic layers. Development. 131(6):1331-1342
Orger, M.B., Gahtan, E., Muto, A., Page-McCaw, P., Smear, M.C., and Baier, H. (2004) Behavioral screening assays in zebrafish. The Zebrafish: Genetics, Genomics and Informatics, 2nd ed., Methods Cell Biol.. 77:53-68
Page-McCaw, P.S., Chung, S.C., Muto, A., Roeser, T., Staub, W., Finger-Baier, K.C., Korenbrot, J.I., and Baier, H. (2004) Retinal network adaptation to bright light requires tyrosinase. Nat. Neurosci.. 7(12):1329-1336
Goldsmith, P., Baier, H., and Harris, W.A. (2003) Two zebrafish mutants, ebony and ivory, uncover benefits of neighborhood on photoreceptor survival. J. Neurobiol.. 57(3):235-245
Loosli, F., Staub, W., Finger-Baier, K.C., Ober, E.A., Verkade, H., Wittbrodt, J., and Baier, H. (2003) Loss of eyes in zebrafish caused by mutation of chokh/rx3. EMBO Rep.. 4(9):894-899
Roeser, T. and Baier, H. (2003) Visuomotor behaviors in larval zebrafish after GFP-guided laser ablation of the optic tectum. J. Neurosci.. 23(9):3726-3734
Xiao, T., Shoji, W., Zhou, W., Su, F., and Kuwada, J.Y. (2003) Transmembrane Sema4E guides branchiomotor axons to their targets in zebrafish. J. Neurosci.. 23(10):4190-4198
Baraban, S., Castro, P., and Baier, H. (2002) Identification of seizure-resistant zebrafish mutants. Epilepsia. 43(7):238
Xiao, T. (2002) Functional analysis of zebrafish semaphorin4E. Ph.D. Thesis, University of Michigan.
Kay, J.N., Finger-Baier, K.C., Roeser, T., Staub, W., and Baier, H. (2001) Retinal ganglion cell genesis requires lakritz, a zebrafish atonal homolog. Neuron. 30(3):725-736
Baier, H. (2000) Zebrafish on the move: towards a behavior-genetic analysis of vertebrate vision. Curr. Opin. Neurobiol.. 10(4):451-455
Baier, H. and Copenhagen, D. (2000) Combining physiology and genetics in the zebrafish retina. J. Physiol. (Lond.). 524(1):135-146
Orger, M.B., Smear, M.C., Anstis, S.M., and Baier, H. (2000) Perception of Fourier and non-Fourier motion by larval zebrafish. Nat. Neurosci.. 3(11):1128-1133
Neuhauss, S.C.F., Biehlmaier, O., Seeliger, M.W., Das, T., Kohler, K., Harris, W.A., and Baier, H. (1999) Genetic disorders of vision revealed by a behavioral screen of 400 essential loci in zebrafish. J. Neurosci.. 19(19):8603-8615
Baier, H., Klostermann, S., Trowe, T., Karlstrom, R.O., Nüsslein-Volhard, C., and Bonhoeffer, F. (1996) Genetic dissection of the retinotectal projection. Development. 123:415-425
Geisler, R., Rauch, G.J., Baier, H., van Bebber, F., Brobeta, L., Dekens, M.P., Finger, K., Fricke, C., Gates, M.A., Geiger, H., Geiger-Rudolph, S., Gilmour, D., Glaser, S., Gnugge, L., Habeck, H., Hingst, K., Holley, S., Keenan, J., Kirn, A., Knaut, H., Lashkari, D., Maderspacher, F., Martyn, U., Neuhauss, S., Neumann, C., Nicolson, T., Pelegri, F., Ray, R., Rick, J.M., Roehl, H., Roeser, T., Schauerte, H.E., Schier, A.F., Schönberger, U., Schönthaler, H.-B., Schulte-Merker, S., Seydler, C., Talbot, W.S., Weiler, C., Nüsslein-Volhard, C., and Haffter, P. (1999) A radiation hybrid map of the zebrafish genome. Nat. Genet.. 23(1):86-89
Karlstrom, R.O., Trowe, T., Klostermann, S., Baier, H., Brand, M., Crawford, A.D., Grunewald, B., Haffter, P., Hoffman, H., Meyer, S.U., Muller, B.K., Richter, S., van Eeden, F.J., Nüsslein-Volhard, C., and Bonhoeffer, F. (1996) Zebrafish mutations affecting retinotectal axon pathfinding. Development. 123:427-438
Trowe, T., Klostermann, S., Baier, H., Granato, M., Crawford, A.D., Grunewald, B., Hoffman, H., Karlstrom, R.O., Meyer, S.U., Muller, B., Richter, S., Nüsslein-Volhard, C., and Bonhoeffer, F. (1996) Mutations disrupting the ordering and topographic mapping of axons in the retinotectal projection of the zebrafish, Danio rerio. Development. 123:439-450
Baier, H. and Korsching, S. (1994) Olfactory glomeruli in the zebrafish form an invariant pattern and are identifiable across animals. J. Neurosci.. 14:219-230
Baier, H., Rotter, S., and Korsching, S. (1994) Connectional topography in the zebrafish olfactory system: random positions but regular spacing of sensory neurons projecting to an individual glomerulus. Proc. Natl. Acad. Sci. USA. 91:11646-11650