Research
General Information
ZIRC
ZFIN ID: ZDB-LAB-040113-1
Lewis Lab
Department of Physiology, Development and Neuroscience
University of Cambridge
Anatomy Building
Downing Street
Cambridge CB2 3DY
UNITED KINGDOM
Contact Info:
Contact Person: Lewis, Katharine E.
Phone: +44 (0)1223 339543
Fax: (01223) 333786
Email: KEL36@cam.ac.uk
URL: http://www.pdn.cam.ac.uk/staff/lewis/
Line Designation: cu 		Lab Members:
Lewis, Katharine E. , PI/Director
England, Sam , Post-Doc
de Jager, Sarah , Post-Doc
Cerda, Gustavo , Graduate Student
Schulte, Claus , Graduate Student
Weierud, Frida , Graduate Student
Dyl, Tomasz , Technical Staff
McNabb, Adrian , Technical Staff
Statement of Research Interests:

We are interested in how different types of neurons are specified in the zebrafish spinal cord. Please see our web page for more details.

Zebrafish Publications of Lab members :
Cerda, G.A., Hargrave, M., and Lewis, K.E. (2009) RNA profiling of FAC-sorted neurons from the developing zebrafish spinal cord. Dev. Dyn.. 238(1):150-161
Wotton, K.R., Weierud, F.K., Juárez-Morales, J.L., Alvares, L.E., Dietrich, S., and Lewis, K.E. (2009) Conservation of gene linkage in dispersed vertebrate NK homeobox clusters. Dev. Genes Evol.. 219(9-10):481-496
Batista, M.F., and Lewis, K.E. (2008) Pax2/8 act redundantly to specify glycinergic and GABAergic fates of multiple spinal interneurons. Dev. Biol.. 323(1):88-97
Batista, M.F., Jacobstein, J., and Lewis, K.E. (2008) Zebrafish V2 cells develop into excitatory CiD and Notch signalling dependent inhibitory VeLD interneurons. Dev. Biol.. 322(2):263-275
Wotton, K.R., Weierud, F.K., Dietrich, S., and Lewis, K.E. (2008) Comparative genomics of Lbx loci reveals conservation of identical Lbx ohnologs in bony vertebrates. BMC Evol. Biol.. 8:171
Lewis, K.E. (2006) How do genes regulate simple behaviours? Understanding how different neurons in the vertebrate spinal cord are genetically specified.. Philos Trans R Soc Lond B Biol Sci.. 361(1465):45-66
Lupo, G., Harris, W.A., and Lewis, K.E. (2006) Mechanisms of ventral patterning in the vertebrate nervous system. Nat Rev Neurosci. 7(2):103-114
Lewis, K.E., Bates, J., and Eisen, J.S. (2005) Regulation of iro3 expression in the zebrafish spinal cord. Dev. Dyn.. 232(1):140-148
Lewis, K.E., and Eisen, J.S. (2004) Paraxial mesoderm specifies zebrafish primary motoneuron subtype identity. Development. 131(4):891-902
Wolff, C., Roy, S., Lewis, K.E., Schauerte, H., Joerg-Rauch, G., Kirn, A., Weiler, C., Geisler, R., Haffter, P., Ingham, P.W. (2004) iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo. Genes Dev.. 18(13):1565-1576
Lewis, K.E. and Eisen, J.S. (2003) From cells to circuits: development of the zebrafish spinal cord. Prog. Neurobiol.. 69(6):419-449
Lewis, K.E. and Eisen, J.S. (2001) Hedgehog signaling is required for primary motoneuron induction in zebrafish. Development. 128(18):3485-3495
Varga, Z.M., Amores, A., Lewis, K.E., Yan, Y.-L., Postlethwait, J.H., Eisen, J.S., and Westerfield, M. (2001) Zebrafish smoothened functions in ventral neural tube specification and axon tract formation. Development. 128(18):3497-3509
Lewis, K.E., Concordet, J.P., and Ingham, P.W. (1999) Characterisation of a second patched gene in the zebrafish Danio rerio and the differential response of patched genes to hedgehog signalling. Dev. Biol.. 208:14-29
Lewis, K.E., Currie, P.D., Roy, S., Schauerte, H., Haffter, P., and Ingham, P.W. (1999) Control of muscle cell-type specification in the zebrafish embryo by hedgehog signalling. Dev. Biol.. 216(2):469-480
Concordet, J.P., Lewis, K.E., Moore, J.W., Goodrich, L.V., Johnson, R.L., Scott, M.P., and Ingham, P.W. (1996) Spatial regulation of a zebrafish patched homologue reflects the roles of sonic hedgehog and protein kinase A in neural tube and somite patterning. Development. 122(9):2835-2846