ZFIN ID: ZDB-LAB-190514-1
Zhenghong Lab
PI/Director: Zhenghong, Zuo
Contact Person: He, Chengyong
Email: hecy@xmu.edu.cn
URL:
Address: F201, Huang Chaoyang Building, Environment Toxicology Group, School of Life Sciences, Xiamen University, Xiamen, 361102
Country: China
Phone: 86+15860784275
Fax: 86+5922181015
Line Designation: xmu


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 2 genomic features


STATEMENT OF RESEARCH INTERESTS
We investigate the relationship of persistent organic pollutants and emerging pollutants (such as polycyclic aromatic hydrocarbon, polychlorinated biphenyls, organotins, and emerging pesticides) exposure with health outcomes (diabetes, neonatal birth defects, cardiovascular diseases, neurodegenerative diseases, and polycystic ovary syndrome) through environmental epidemiological studies; explore the toxicological mechanisms of adverse effects caused by pollutants exposure at environmental doses via experimental animals and in vitro models;look for potential cellular and molecular biomarkers as diagnostic and prognostic tools for pollution monitoring.


LAB MEMBERS
Chao, Shen Graduate Student Jinpeng, Ruan Graduate Student Yixi, Zhou Graduate Student
He, Chengyong Administrative Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Cai, H., Zheng, N., Tang, C., Zhang, Y., Zuo, Z., He, C. (2024) Tributyltin causes generational neurodevelopmental toxicity and the protective effect of folic acid in zebrafish. Journal of environmental sciences (China). 137:615625615-625
Wang, L., Liang, C., Zheng, N., Yang, C., Yan, S., Wang, X., Zuo, Z., He, C. (2023) Kidney injury contributes to edema of zebrafish larvae caused by quantum dots. The Science of the total environment. 908:168420
Wu, M., Zheng, N., Zhan, X., He, J., Xiao, M., Zuo, Z., He, C. (2023) Icariin induces developmental toxicity via thyroid hormone disruption in zebrafish larvae. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 182:114155
Lin, T., Zhou, L., Chen, Z., Wang, L., Yang, J., Wang, S., Chen, X., Zuo, Z., He, C., Guo, L. (2023) Exposure to echimidine impairs the heart development and function of zebrafish larvae. Ecotoxicology and environmental safety. 266:115574115574
Shen, C., Tang, C., Zhu, K., He, C., Yang, C., Zuo, Z. (2023) Toxicity and ecological risk assessment for two AhR agonistic pesticides mepanipyrim and cyprodinil and their metabolites. Environmental science and pollution research international. 30(20):58944-58955
Shen, C., He, J., Zhu, K., Zheng, N., Yu, Y., He, C., Yang, C., Zuo, Z. (2023) Mepanipyrim induces cardiotoxicity of zebrafish (Danio rerio) larvae via promoting AhR-regulated COX expression pathway. Journal of environmental sciences (China). 125:650-661
Shen, C., Cai, Y., Li, J., He, C., Zuo, Z. (2023) Mepanipyrim induces visual developmental toxicity and vision-guided behavioral alteration in zebrafish larvae. Journal of environmental sciences (China). 124:76-88
Zheng, N., Sun, X., Shi, Y., Chen, L., Wang, L., Cai, H., Han, C., Liao, T., Yang, C., Zuo, Z., He, C. (2022) The valence state of iron-based nanomaterials determines the ferroptosis potential in a zebrafish model. The Science of the total environment. 855:158715
Tang, C., Zhu, Y., Yang, C., He, C., Zuo, Z. (2022) Reproductive toxicity of long-term exposure to environmental relevant concentrations of cyprodinil in female zebrafish (Danio rerio). The Science of the total environment. 846:157504
Shen, C., Zhao, X., He, C., Zuo, Z. (2022) Developmental toxicity and neurotoxicity assessment of R-, S-, and RS-propylene glycol enantiomers in zebrafish (Danio rerio) larvae. Environmental science and pollution research international. 29(20):30537-30547
Tang, C., Zhu, Y., Laziyan, Y., Yang, C., He, C., Zuo, Z. (2021) Long-term exposure to cyprodinil causes abnormal zebrafish aggressive and antipredator behavior through the hypothalamic-pituitary-interrenal axis. Aquatic toxicology (Amsterdam, Netherlands). 241:106002
Zheng, N., Yan, J., Qian, W., Song, C., Zuo, Z., He, C. (2021) Comparison of developmental toxicity of different surface modified CdSe/ZnS QDs in zebrafish embryos. Journal of environmental sciences (China). 100:240-249
Tang, C., Shen, C., Zhu, K., Zhou, Y., Chuang, Y.J., He, C., Zuo, Z. (2020) Exposure to the AhR agonist cyprodinil impacts the cardiac development and function of zebrafish larvae. Ecotoxicology and environmental safety. 201:110808
Shen, C., Zhou, Y., Tang, C., He, C., Zuo, Z. (2020) Developmental exposure to mepanipyrim induces locomotor hyperactivity in zebrafish (Danio rerio) larvae. Chemosphere. 256:127106
Yan, J., Chen, S., Zuo, Z., He, C., Yi, M. (2020) Graphene oxide quantum dot exposure induces abnormalities in locomotor activities and mechanisms in zebrafish (Danio rerio). Journal of applied toxicology : JAT. 40(6):794-803
Zhou, Y., Shen, C., Du, H., Bao, Y., He, C., Wang, C., Zuo, Z. (2018) Bioassay system for the detection of aryl hydrocarbon receptor agonists in waterborne pesticides using zebrafish cyp1a1 promoter-luciferase recombinant hepatic cells. Chemosphere. 220:61-68
Shen, C., Zhou, Y., Ruan, J., Chuang, Y.J., Wang, C., Zuo, Z. (2018) Generation of a Tg(cyp1a-12DRE:EGFP) transgenic zebrafish line as a rapid in vivo model for detecting dioxin-like compounds. Aquatic toxicology (Amsterdam, Netherlands). 205:174-181