ZFIN ID: ZDB-LAB-131203-3
Yuh Lab
PI/Director: Yuh, Chiou-Hwa (Cathy)
Contact Person: Lin, Yu-Ju
Email: sophylin@nhri.edu.tw
URL: https://mg.nhri.edu.tw/tw/investigators/dr-chiou-hwa-yuh/
Address: #35 Keyan Road, Zhunan Town, Miaoli County, Taiwan, R.O.C. R2-3111, Institute of Molecular and Genomic Medicine, National Health Research Institutes
Country: Taiwan
Phone: 011-886-37-206166 extension 35337
Fax: 011-886-37-586459
Line Designation: nn


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 22 genomic features


STATEMENT OF RESEARCH INTERESTS
Dr. Yuh, an accomplished researcher, earned her Ph.D. from the Institute of Microbiology and Immunology at National Yang-Ming Medical College, making significant contributions to understanding the hepatitis B virus's enhancer II. Her work at the California Institute of Technology focused on the Endomesoderm Gene Regulatory Network in sea urchin. Since joining IMGM of NHRI in 2004, she has utilized zebrafish to investigate embryonic gene regulatory networks, with a keen interest in cancer development. Currently, her research emphasizes dysregulated metabolism in hepatocarcinogenesis, exploring therapeutic avenues for NAFLD and HCC through the STAT3/AMPK/PFKL axis. Her team is also developing a drug screening platform using Artificial Intelligent-Phenotypic Response Surface (AI-PRS) in zebrafish models, aligning with her broader focus on liver diseases, including NAFLD, liver cancer, gastric cancer, and congenital myopathy. This approach aims to optimize treatment strategies by considering individual biological differences and repurposing existing drugs, contributing to enhanced understanding and improved interventions for various liver-related conditions.


LAB MEMBERS
Hsiao, He-Yun Graduate Student Huang, Yi-Sian Graduate Student Ma, Chung-Yung Graduate Student
Shi, Yi-Cheng Graduate Student Wu, Pei-En Graduate Student Lin, Kuan-Hao Research Staff
Lin, Yu-Ju Research Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Hou, C.Y., Ma, C.Y., Lin, Y.J., Huang, C.L., Wang, H.D., Yuh, C.H. (2022) WNK1-OSR1 Signaling Regulates Angiogenesis-Mediated Metastasis towards Developing a Combinatorial Anti-Cancer Strategy. International Journal of Molecular Sciences. 23(20):
Lin, H.D., Tseng, Y.K., Yuh, C.H., Chen, S.C. (2021) Low concentrations of 4-ABP promote liver carcinogenesis in human liver cells and a zebrafish model. Journal of hazardous materials. 423:126954
Hsu, P.J., Wang, H.D., Tseng, Y.C., Pan, S.W., Sampurna, B.P., Jong, Y.J., Yuh, C.H. (2021) L-Carnitine ameliorates congenital myopathy in a tropomyosin 3 de novo mutation transgenic zebrafish. Journal of Biomedical Science. 28:8
Wu, S.Y., Yang, W.Y., Cheng, C.C., Lin, K.H., Sampurna, B.P., Chan, S.M., Yuh, C.H. (2020) Low molecular weight fucoidan inhibits hepatocarcinogenesis and nonalcoholic fatty liver disease in zebrafish via ASGR/STAT3/HNF4A signaling. Clinical and translational medicine. 10:e252
Tseng, L.L., Cheng, H.H., Yeh, T.S., Huang, S.C., Syu, Y.Y., Chuu, C.P., Yuh, C.H., Kung, H.J., Wang, W.C. (2020) Targeting the histone demethylase PHF8-mediated PKCα-Src-PTEN axis in HER2-negative gastric cancer. Proceedings of the National Academy of Sciences of the United States of America. 117(40):24859-24866
Wu, S.Y., Yang, W.Y., Cheng, C.C., Hsiao, M.C., Tsai, S.L., Lin, H.K., Lin, K.H., Yuh, C.H. (2020) Low Molecular Weight Fucoidan Prevents Radiation-Induced Fibrosis and Secondary Tumors in a Zebrafish Model. Cancers. 12(6):
Cheng, C.C., Yang, W.Y., Hsiao, M.C., Lin, K.H., Lee, H.W., Yuh, C.H. (2020) Transcriptomically Revealed Oligo-Fucoidan Enhances the Immune System and Protects Hepatocytes via the ASGPR/STAT3/HNF4A Axis. Biomolecules. 10(6):
Wu, S.Y., Chou, H.Y., Tsai, H.C., Anbazhagan, R., Yuh, C.H., Yang, J.M., Chang, Y.H. (2020) Amino acid-modified PAMAM dendritic nanocarriers as effective chemotherapeutic drug vehicles in cancer treatment: a study using zebrafish as a cancer model. RSC Advances. 10:20682-20690
Sie, Z.L., Li, R.Y., Sampurna, B.P., Hsu, P.J., Liu, S.C., Wang, H.D., Huang, C.L., Yuh, C.H. (2020) WNK1 Kinase Stimulates Angiogenesis to Promote Tumor Growth and Metastasis. Cancers. 12(3):
Addisu, K.D., Hsu, W.H., Hailemeskel, B.Z., Andrgie, A.T., Chou, H.Y., Yuh, C.H., Lai, J.Y., Tsai, H.C. (2019) Mixed Lanthanide Oxide Nanoparticles Coated with Alginate-Polydopamine as Multifunctional Nanovehicles for Dual Modality: Targeted Imaging and Chemotherapy. ACS biomaterials science & engineering. 5:5453-5469
Su, Z.L., Su, C.W., Huang, Y.L., Yang, W.Y., Sampurna, B.P., Ouchi, T., Lee, K.L., Wu, C.S., Wang, H.D., Yuh, C.H. (2019) A Novel AURKA Mutant-Induced Early-Onset Severe Hepatocarcinogenesis Greater than Wild-Type via Activating Different Pathways in Zebrafish. Cancers. 11(7)
Lin, H.S., Huang, Y.L., Wang, Y.S., Hsiao, E., Hsu, T.A., Shiao, H.Y., Jiaang, W.T., Sampurna, B.P., Lin, K.H., Wu, M.S., Lai, G.M., Yuh, C.H. (2019) Identification of Novel Anti-Liver Cancer Small Molecules with Better Therapeutic Index than Sorafenib via Zebrafish Drug Screening Platform. Cancers. 11(6)
Chou, Y.T., Chen, L.Y., Tsai, S.L., Tu, H.C., Lu, J.W., Ciou, S.C., Wang, H.D., Yuh, C.H. (2018) Ribose-5-Phosphate Isomerase A Overexpression Promotes Liver Cancer Development in Transgenic Zebrafish via Activation of ERK and β-catenin Pathways. Carcinogenesis. 40(3):461-473
Chou, Y.T., Jiang, J.K., Yang, M.H., Lu, J.W., Lin, H.K., Wang, H.D., Yuh, C.H. (2018) Identification of a noncanonical function for ribose-5-phosphate isomerase A promotes colorectal cancer formation by stabilizing and activating β-catenin via a novel C-terminal domain. PLoS Biology. 16:e2003714
Wu, S.Y., Chou, H.Y., Yuh, C.H., Mekuria, S.L., Kao, Y.C., Tsai, H.C. (2017) Radiation-Sensitive Dendrimer-Based Drug Delivery System. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 5:1700339
Hsu, D.S., Hwang, W.L., Yuh, C.H., Chu, C.H., Ho, Y.H., Chen, P.B., Lin, H.S., Lin, H.K., Wu, S.P., Lin, C.Y., Hsu, W.H., Lan, H.Y., Wang, H.J., Tai, S.K., Hung, M.C., Yang, M.H. (2017) Lymphotoxin-beta interacts with methylated EGFR to mediate acquired resistance to cetuximab in head and neck cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 23(15):4388-4401
Yang, C.H., Yeh, Y.J., Wang, J.Y., Liu, Y.W., Chen, Y.L., Cheng, H.W., Cheng, C.M., Chuang, Y.J., Yuh, C.H., Chen, Y.R. (2017) NEAP/DUSP26 suppresses receptor tyrosine kinases and regulates neuronal development in zebrafish. Scientific Reports. 7:5241
Huang, Y.C., Lin, S.J., Shih, H.Y., Chou, C.H., Chu, H.H., Chiu, C.C., Yuh, C.H., Yeh, T.H., Cheng, Y.C. (2017) Epigenetic regulation of NOTCH1 and NOTCH3 by KMT2A inhibits glioma proliferation. Oncotarget. 8:63110-63120
Tu, H.C., Hsiao, Y.C., Yang, W.Y., Tsai, S.L., Lin, H.K., Liao, C.Y., Lu, J.W., Chou, Y.T., Wang, H.D., Yuh, C.H. (2017) Up-regulation of golgi α-mannosidase IA and down-regulation of golgi α-mannosidase IC activates unfolded protein response during hepatocarcinogenesis. Hepatology communications. 1:230-247
You, M.S., Jiang, Y.J., Yuh, C.H., Wang, C.M., Tang, C.H., Chuang, Y.J., Lin, B.H., Wu, J.L., Hwang, S.L. (2016) A Sketch of the Taiwan Zebrafish Core Facility. Zebrafish. 13 Suppl 1:S24-9
Lu, J.W., Liao, C.Y., Yang, W.Y., Lin, Y.M., Jin, S.L., Wang, H.D., and Yuh, C.H. (2014) Overexpression of endothelin 1 triggers hepatocarcinogenesis in zebrafish and promotes cell proliferation and migration through the AKT pathway. PLoS One. 9(1):e85318
Yeh, D.W., Liu, Y.L., Lo, Y.C., Yuh, C.H., Yu, G.Y., Lo, J.F., Luo, Y., Xiang, R., and Chuang, T.H. (2013) Toll-like receptor 9 and 21 have different ligand recognition profiles and cooperatively mediate activity of CpG-oligodeoxynucleotides in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 110(51):20711-20716
Lu, J.W., Yang, W.Y., Tsai, S.M., Lin, Y.M., Chang, P.H., Chen, J.R., Wang, H.D., Wu, J.L., Jin, S.L., and Yuh, C.H. (2013) Liver-Specific Expressions of HBx and src in the p53 Mutant Trigger Hepatocarcinogenesis in Zebrafish. PLoS One. 8(10):e76951
Chen, W., Tseng, X., Lin, G., Schreiner, A., Chen, H., Voigt, M.M., Yuh, C., Wu, J., Huang, S.S., and Huang, J. (2013) The Ortholog of LYVE-1 Is Required for Thoracic Duct Formation in Zebrafish. CellBio. 2(4):228-247
Lu, J.W., Yang, W.Y., Lin, Y.M., Jin, S.L., and Yuh, C.H. (2013) Hepatitis B virus X antigen and aflatoxin B1 synergistically cause hepatitis, steatosis and liver hyperplasia in transgenic zebrafish. Acta histochemica. 115(7):728-39
Tseng, W.F., Jang, T.H., Huang, C.B., and Yuh, C.H. (2011) An evolutionarily conserved kernel of gata5, gata6, otx2 and prdm1a operates in the formation of endoderm in zebrafish. Developmental Biology. 357(2):541-57
Lu, J.W., Hsia, Y., Tu, H.C., Hsiao, Y.C., Yang, W.Y., Wang, H.D., and Yuh, C.H.. (2011) Liver development and cancer formation in zebrafish. Birth defects research. Part C, Embryo today : reviews. 93(2):157-172
Chao, C.H., Wang, H.D., and Yuh, C.H. (2010) Complexity of cis-regulatory organization of six3a during forebrain and eye development in zebrafish. BMC Developmental Biology. 10:35
Chen, H.L., Yuh, C.H., and Wu, K.K. (2010) Nestin Is Essential for Zebrafish Brain and Eye Development through Control of Progenitor Cell Apoptosis. PLoS One. 5(2):e9318
Chan, T.M., Longabaugh, W., Bolouri, H., Chen, H.L., Tseng, W.F., Chao, C.H., Jang, T.H., Lin, Y.I., Hung, S.C., Wang, H.D., and Yuh, C.H. (2009) Developmental gene regulatory networks in the zebrafish embryo. Biochimica et biophysica acta. Gene regulatory mechanisms. 1789(4):279-298
Chan, T.M., Chao, C.H., Wang, H.D., Yu, Y.J., and Yuh, C.H. (2009) Functional analysis of the evolutionarily conserved Cis-regulatory elements on the Sox17 gene in zebrafish. Developmental Biology. 326(2):456-470