Gene

klhl3

ID

ZDB-GENE-120203-4

Name

kelch-like family member 3

Symbol

klhl3 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to have actin binding activity. Predicted to be involved in several processes, including cellular protein metabolic process; distal tubule morphogenesis; and renal sodium ion absorption. Predicted to localize to Cul3-RING ubiquitin ligase complex and cytosol. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Orthologous to human KLHL3 (kelch like family member 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With klhl3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Pseudohypoaldosteronism, type IID	614495

Associated With klhl3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000210	BTB/POZ domain
Domain	IPR011705	BTB/Kelch-associated
Domain	IPR030578	Kelch-like protein 3, BACK domain
Family	IPR017096	BTB-kelch protein
Homologous_superfamily	IPR011043	Galactose oxidase/kelch, beta-propeller
Homologous_superfamily	IPR011333	SKP1/BTB/POZ domain superfamily
Homologous_superfamily	IPR015915	Kelch-type beta propeller
Repeat	IPR006652	Kelch repeat type 1