Gene

scn3b

ID
ZDB-GENE-070920-2
Name
sodium channel, voltage-gated, type III, beta
Symbol
scn3b Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 15 Mapping Details/Browsers
Description
Predicted to have ion channel binding activity and sodium channel inhibitor activity. Predicted to be involved in regulation of heart rate by cardiac conduction; regulation of sodium ion transmembrane transporter activity; and ventricular cardiac muscle cell action potential. Predicted to localize to voltage-gated sodium channel complex. Human ortholog(s) of this gene implicated in Brugada syndrome 7. Is expressed in atrium; brain; cardiac ventricle; and eye. Orthologous to human SCN3B (sodium voltage-gated channel beta subunit 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With scn3b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Brugada syndrome 7 Alliance Atrial fibrillation, familial, 16 613120
Brugada syndrome 7 Alliance Brugada syndrome 7 613120
Associated With scn3b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003599 Immunoglobulin subtype
Domain IPR007110 Immunoglobulin-like domain
Domain IPR013106 Immunoglobulin V-set domain
Family IPR027098 Sodium channel subunit beta-1/beta-3
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Immunoglobulin V-set domain Sodium channel subunit beta-1/beta-3
UniProtKB:F8W4B3 241
UniProtKB:A0A8M3APT8 222
UniProtKB:Q06W27 220
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations