PUBLICATION
Thyroid hormone actions on male reproductive system of teleost fish
- Authors
- Tovo-Neto, A., da Silva Rodrigues, M., Habibi, H.R., Nóbrega, R.H.
- ID
- ZDB-PUB-180422-4
- Date
- 2018
- Source
- General and comparative endocrinology 265: 230-236 (Review)
- Registered Authors
- Keywords
- Adult testis, Reproduction, Sex differentiation, Spermatogenesis, Teleost fish, Testicular development, Thyroid hormones
- MeSH Terms
-
- Animals
- Fishes/physiology*
- Male
- Reproduction/drug effects
- Reproduction/physiology*
- Sex Differentiation/drug effects
- Sex Differentiation/physiology
- Testis/drug effects*
- Testis/embryology
- Testis/metabolism
- Thyroid Gland/drug effects
- Thyroid Gland/metabolism
- Thyroid Hormones/pharmacology*
- PubMed
- 29678724 Full text @ Gen. Comp. Endocrinol.
Citation
Tovo-Neto, A., da Silva Rodrigues, M., Habibi, H.R., Nóbrega, R.H. (2018) Thyroid hormone actions on male reproductive system of teleost fish. General and comparative endocrinology. 265:230-236.
Abstract
Thyroid hormones (THs) play important roles in the regulation of many biological processes of vertebrates, such as growth, metabolism, morphogenesis and reproduction. An increasing number of studies have been focused on the involvement of THs in the male reproductive system of vertebrates, in particular of fish. Therefore, this mini-review aims to summarize the main findings on THs role in male reproductive system of fish, focusing on sex differentiation, testicular development and spermatogenesis. The existing data in the literature have demonstrated that THs exert their roles at the different levels of the hypothalamic-pituitary-gonadal (HPG) axis. In general a positive correlation has been shown between THs and fish reproductive status; where THs are associated with testicular development, growth and maturation. Recently, the molecular mechanisms underlying the role of THs in spermatogenesis have been unraveled in zebrafish testis. THs promote germ cell proliferation and differentiation by increasing stimulatory growth factor of spermatogenesis. In addition, THs enhanced the gonadotropin-induced androgen release in zebrafish testis. Next to their functions in the adult testis, THs are involved in the gonadal sex differentiation through modulating sex-related gene expression, and testicular development via regulation of Sertoli cell proliferation. In conclusion, this mini-review showed that THs modulate the male reproductive system during the different life stages. The physiological and molecular mechanisms showed a link between the thyroid and reproduction, suggesting a possibly co-evolution and interdependence of these two systems.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping