PUBLICATION
Simple animal models for amyotrophic lateral sclerosis drug discovery
- Authors
- Patten, S.A., Parker, J.A., Wen, X.Y., Drapeau, P.
- ID
- ZDB-PUB-160602-5
- Date
- 2016
- Source
- Expert opinion on drug discovery 11(8): 797-804 (Review)
- Registered Authors
- Keywords
- Amyotrophic lateral sclerosis, Drosophila, chemical genetics, drug discovery, C. elegans, zebrafish
- MeSH Terms
-
- Amyotrophic Lateral Sclerosis/drug therapy*
- Amyotrophic Lateral Sclerosis/genetics
- Animals
- Animals, Genetically Modified
- Caenorhabditis elegans
- Disease Models, Animal
- Drosophila
- Drug Design*
- Drug Discovery/methods*
- Humans
- Molecular Targeted Therapy
- Zebrafish
- PubMed
- 27249162 Full text @ Expert Opin. Drug Discov.
Citation
Patten, S.A., Parker, J.A., Wen, X.Y., Drapeau, P. (2016) Simple animal models for amyotrophic lateral sclerosis drug discovery. Expert opinion on drug discovery. 11(8):797-804.
Abstract
Introduction Simple animal models have enabled great progress in uncovering the disease mechanisms of amyotrophic lateral sclerosis (ALS) and are helping in the selection of therapeutic compounds through chemical genetic approaches.
Areas covered Within this article, the authors provide a concise overview of simple model organisms, C. elegans, Drosophila and zebrafish, which have been employed to study ALS and discuss their value to ALS drug discovery. In particular, the authors focus on innovative chemical screens that have established simple organisms as important models for ALS drug discovery.
Expert opinion There are several advantages of using simple animal model organisms to accelerate drug discovery for ALS. It is the authors' particular belief that the amenability of simple animal models to various genetic manipulations, the availability of a wide range of transgenic strains for labelling motoneurons and other cell types, combined with live imaging and chemical screens should allow for new detailed studies elucidating early pathological processes in ALS and subsequent drug and target discovery.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping