PUBLICATION
Reversible and Irreversible Aggregation of Proteins from the FET Family: Influence of Repeats in Protein Chain on Its Aggregation Capacity
- Authors
- Galzitskaya, O.V.
- ID
- ZDB-PUB-170214-165
- Date
- 2016
- Source
- Current Protein & Peptide Science 17: 319-31 (Journal)
- Registered Authors
- Keywords
- Amyotrophic lateral sclerosis, disordered regions, motifs of low complexity, proteinopathies, repeats
- MeSH Terms
-
- Amino Acid Sequence
- Animals
- Cytosol/metabolism
- Humans
- Protein Aggregates*
- RNA-Binding Proteins/chemistry*
- RNA-Binding Proteins/metabolism*
- Repetitive Sequences, Amino Acid*
- Zinc Fingers
- PubMed
- 26100283 Full text @ Curr. Protein Pept. Sci.
Citation
Galzitskaya, O.V. (2016) Reversible and Irreversible Aggregation of Proteins from the FET Family: Influence of Repeats in Protein Chain on Its Aggregation Capacity. Current Protein & Peptide Science. 17:319-31.
Abstract
The discovery of protein chain regions responsible for protein aggregation is an important result of studying of the molecular mechanisms of prion diseases and different proteinopathies associated with the formation of pathological aggregations through the prion mechanism. The ability to control aggregation of proteins could be an important tool in the arsenal of the drug development. Here we demonstrate, on an example of RNA-binding proteins of the FET family from six animal species (human, gorilla, pig, mouse, chicken, zebra fish), the possible role of repeats within the disordered regions. For these proteins, different repeats are revealed in the prion-like (N-terminal disordered) domains, and in the C-terminal disordered regions, predicted using bioinformatics methods. Moreover, we have found that in more complex organisms the number of repeats is increased. It can be hypothesized that the presence of a large number of repeats in the disordered regions in the proteins of the FET-family could both modulate and accelerate the formation of a dynamic cross-beta structure, and pathological aggregates.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping