PUBLICATION
1,8-cineole protected human lipoproteins from modification by oxidation and glycation and exhibited serum lipid-lowering and anti-inflammatory activity in zebrafish
- Authors
- Cho, K.H.
- ID
- ZDB-PUB-121116-1
- Date
- 2012
- Source
- BMB reports 45(10): 565-570 (Journal)
- Registered Authors
- Keywords
- anti-oxidant, atherosclerosis, cineole, lipoprotein, zebrafish
- MeSH Terms
-
- Animals
- Anti-Inflammatory Agents/pharmacology*
- Antioxidants/pharmacology
- Cholesterol, Dietary
- Copper/chemistry
- Cyclohexanols/pharmacology*
- Glycosylation
- Humans
- Hypolipidemic Agents/pharmacology*
- Interleukin-6/metabolism
- Lipid Metabolism/drug effects
- Lipoproteins/chemistry
- Lipoproteins/metabolism*
- Lipoproteins, HDL/metabolism
- Lipoproteins, LDL/metabolism
- Monoterpenes/pharmacology*
- Oxidation-Reduction
- Zebrafish/metabolism
- PubMed
- 23101510 Full text @ BMB Rep.
Citation
Cho, K.H. (2012) 1,8-cineole protected human lipoproteins from modification by oxidation and glycation and exhibited serum lipid-lowering and anti-inflammatory activity in zebrafish. BMB reports. 45(10):565-570.
Abstract
We recently reported that a water extract of laurel or turmeric, 1,8-cineole enriched fractions, showed hypolipidemic activity in the zebrafish model. Therefore, the present study investigated the cineole's anti-oxidant and anti-inflammatory activities in lipoprotein metabolism in vitro and in vivo. Cineole had inhibitory effects on cupric ion-mediated oxidation of lipoproteins in general, while simultaneously enhancing ferric ion removal ability in high-density lipoprotein (HDL). Hypercholesterolemia was induced in zebrafish using cholesterol-feeding treatment, 4% cholesterol, for 3 weeks. After feeding with or without the addition of cineole, the results revealed that cineole possessed lipid-lowering and anti-inflammatory activities in hypercholesterolemic zebrafish. In addition, serum amyloid A and interleukin-6 levels were lowered and lipid accumulation was decreased in the liver. Conclusively, 1,8-cineole was found to have anti-oxidant activities in lipoprotein metabolism both in vitro and in vivo with simultaneous reduction of lipid accumulation in the liver of zebrafish.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping