PUBLICATION
Evolution of 11beta-hydroxysteroid dehydrogenase-type 1 and 11beta-hydroxysteroid dehydrogenase-type 3
- Authors
- Baker, M.E.
- ID
- ZDB-PUB-100408-2
- Date
- 2010
- Source
- FEBS letters 584(11): 2279-2284 (Journal)
- Registered Authors
- Keywords
- 11β-Hydroxysteroid dehydrogenase-type 3; 11β-Hydroxysteroid dehydrogenase-type 1; Evolution; Amphioxus; Sea urchin; 11-Keto-testosterone
- MeSH Terms
-
- 11-beta-Hydroxysteroid Dehydrogenase Type 1/genetics*
- 11-beta-Hydroxysteroid Dehydrogenases/genetics*
- Animals
- Cortisone/genetics
- Evolution, Molecular*
- Hydrocortisone/genetics
- Mice
- Rats
- PubMed
- 20350543 Full text @ FEBS Lett.
Citation
Baker, M.E. (2010) Evolution of 11beta-hydroxysteroid dehydrogenase-type 1 and 11beta-hydroxysteroid dehydrogenase-type 3. FEBS letters. 584(11):2279-2284.
Abstract
A key regulator of glucocorticoid action is 11beta-hydroxysteroid dehydrogenase-type 1 (11beta-HSD1), which catalyzes the conversion of cortisone to cortisol, the biologically active glucocorticoid. 11beta-HSD1 is a paralog of 11beta-HSD3, whose physiological function remains unclear. As reported here, 11beta-HSD3 has orthologs in sea urchin, amphioxus and Ciona, while 11beta-HSD1 first appears in sharks. Thus, 11beta-HSD3 arose before the evolution of glucocorticoid signaling, suggesting different ancestral function(s) for 11beta-HSD3. Four perplexing findings arise from this evolutionary analysis: (1) 11beta-HSD1 is not present in a ray-finned fish genome, (2) zebrafish and fathead minnow contain two isoforms of 11beta-HSD3; (3) neither rat nor mouse contain 11beta-HSD3 and (4) amphioxus contains 16 11beta-HSD3 paralogs.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping